Basic Information On Aredia
Aredia is a bisphosphonate containing nitrogen. It is used in the treatment of osteoporosis. It is also used in the treatment of hypercalcemia, which means increase of calcium in the body associated with various types of cancers or multiple myeloma. In Paget’s disease the drug is used to strengthen the bones. It is also used in the treatment of bone metastasis or certain bone disorders such as brittle bones or osteogenesis imperfecta. The brand or generic Aredia acts by inhibiting the bone resorption. The drug blocks the dissolution of calcium phosphate of the bones. Also it adsorbs the crystals of calcium phosphate (hydroxyapatite) in the bones. The drug also inhibits the activity of osteoclast and thus inhibits the bone resorption and bone turnover.
Precautions / Side Effects For Aredia
Common side effects of Aredia are black/ tarry stools, abdominal cramps, muscle cramps/ pain/ twitching/ spasms, blood in stools or urine, decreased volume of urine, increased thirst, bleeding gums, chest pain, blurred vision, convulsions, confusion, dizziness, drowsiness, fainting, dry mouth, fever, chills, headache, irregular (slow or fast) heartbeat, loss of appetite, nausea, vomiting (like coffee grounds or blood), mental/ mood changes, nervousness, noisy breathing and tingling or numbness of lower legs, feet or hands. Pamidronic acid may also cause spreading of cancer, sore throat, trembling, unexplained weakness and weight gain.
Rare side effects of brand or generic Aredia may include reddening of eyes, photo-sensitivity in the eyes, tearing of eyes, tightness of the chest, pain or tenderness of the eyes, decrease in vision, hives, itching, sweating, skin rashes, pale skin, difficulty in swallowing, wheezing, irregular breathing, cough, dilation of neck veins, severe fatigue, difficulty or pain during urination, lower side or back pain and mouth ulcers or sores. These side effects of Pamidronic acid must be reported to your doctor.
Aredia Dosage
The recommended dose of Aredia in the treatment of moderate hypercalcemia is 60-90 mg and severe hypercalcemia is 90 mg which is to be administered IV over a period of 2-24 hours as a single dosage. Re-treatment may be done but only with a 7-days elapse. To treat patients with bone diseases related to Paget’s disease (moderate-to-severe) the dose is 30 mg/day for 3 days, to be administered as IV for 4-hours (thus a total of 90 mg). For treating osteolytic bone-lesions of multiple-myeloma the dose is 90 mg/month as a 4-hour IV. For treating osteolytic bone-metastasis of breast-cancer the dose is 90 mg administered every 3-4 weeks as 2-hours IV. Aredia drug may also be given as vitamin D and calcium supplement for patients with risk of vitamin D and calcium deficiency.
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