General Information on Cisplatin
Cisplatin is the generic name of an antineoplastic medication. It has been used as part of chemotherapeutic treatment of several types of cancer, including advanced bladder cancer and metastatic testicular and ovarian cancer.
Cisplatin works by interfering with the growth of cancer cells, which leads to their slower rate of growth, thus keeping their spread in check.
Cisplatin is prescribed as part of a complete combination chemotherapy regime, and it is injected intravenously into the body.
Side effects of Cisplatin
Cisplatin is not be administered in cancer patients who also suffer from hearing impairment, poor bone marrow functioning, and hypersensitivity to platinum or any platinum based product. If the patient has already suffered from an allergy to Cisplatin, it should not be given again. This drug is a pregnancy category D drug, which means that it has been found to be dangerous for the fetus if it is administered during a pregnancy. Therefore, you must use appropriate birth control measures to avoid pregnancy while you are on Cisplatin treatment.
Cisplatin is known to cause severe side effects in certain rare situations. If you experience any of the following, you must alert your doctor at once. These side effects are given below:
- The appearance of blood in the urine, reduced or no urination (signs of kidney damage)
- Ringing in the ears, hearing loss
- Extreme fatigue, fever, blood, tarry or black stools, chills, signs of an infection, easy bleeding and bruising (signs of dangerously reduced bone marrow function or severe blood problems)
- Heart problems, circulation problems
- Vomiting, severe loss of appetite, nausea, diarrhea
- Tingling sensation or numbness
- Increased level of uric acid in the blood, gout
- Abdominal pain, yellowing of the eyes and skin (signs of liver damage)
- Hair loss
Dosage of Cisplatin
Cisplatin will be administered only by qualified medical professionals under close supervision. The medication is available three quantities (50mL, 100mL and 200mL) of multiple dosage vials with the same dosage strength of Cisplatin 1mg/mL. The recommended dose of Cisplatin varies according the type of cancer that is being treated.
The recommended adult daily dose for testicular cancer is 20mg/m2, along with other prescribed chemotherapy drugs. Each chemotherapy cycle would last for 5 days. For ovarian cancer, the recommended dosage of Cisplatin is between 75 and 100 mg/m2, along with other prescribed chemotherapeutic agents intravenously per cycle once in four weeks. For bladder cancer, around 50 to 70 mg/m2 is recommended to be injected intravenously as a single chemotherapeutic agent once in 3-4 weeks. However, this is recommended only for advanced bladder cancer patients who do not have a history of chemotherapy or extensive radiation therapy.
The recommended doses given above may be changed or adjusted by your doctor to suit your own medical condition.
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