Basic Information On Exforge
Exforge is a calcium channel blocker (CCB) belonging to the class of the drugs called dihydropyridine. The drug is used in the treatment and management of hypertension. It is a combination of two drugs that is effectively used particularly in patients who do not respond to monotherapy or whose blood pressure cannot be controlled adequately with monotherapy. Being a CCB the drug acts by inhibiting calcium ion influx into the smooth muscles of the heart (vascular and cardiac muscles). Calcium ions are responsible for the contraction of smooth muscles. The blockage of this activity in-turn results in relaxation of the smooth muscles, selectively the cardiac muscles. Brand or generic Exforge also reduces the peripheral resistance in the heart and therefore reduces the blood pressure.
Precautions / Side Effects For Exforge
Common side effects of Exforge drug are feeling of stuffy nose or runny nose, cough, sore throat, spinning sensation, dizziness, constipation, diarrhea, stomach pain, loss of appetite, dry mouth, redness of the skin, tingly or warm feeling under the skin, sleep disorders like insomnia, anxiety and muscle pain. Serious side effects of Amlodipine/Valsartan include swelling of feet or hands, rapid weight gains, pounding or fast heart beats, feeling like passing out, jaundice like symptoms (such as eyes or skin becoming yellow), chest pain, heavy feeling in the chest, nausea, general feeling of illness, sweating and spreading pain to shoulder or arm.
If you experience the above mentioned serious side effects with Exforge then seek medical attention. If you are already using drugs such as potassium supplements, salt substitutes, medication for any cardiac/h2eart diseases, diuretics or any other blood pressure lowering agent then let you physician know before starting the therapy with Amlodipine/Valsartan. Also let your physician know if you have had liver disease, kidney disease, angina, coronary artery disease, congestive heart failure, vomiting or diarrhea or heart attack in the past.
Exforge Dosage
The starting dose of brand or generic Exforge is recommended to be 5/160 mg administered once daily. The effective dose of Amlodipine is to be 2.5 mg to 10 mg per day and that of Valsartan is 80 mg to 320 mg per day. The maximum dosage of 10 mg Amlodipine and 320 mg of Valsartan should not be exceeded. The anti-hypertensive effect of Exforge is observed within two weeks of administering the drug. If dose adjustment is required then it should be done only after 1 or 2 weeks of the treatment. In elderly patients the therapy with Amlodipine should start with 2.5 mg only as its clearance is decreased with age.
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