General Information on Kombiglyze XR
Kombiglyze XR contains 2 drugs with generic names metformin and saxagliptin. They are used as medications for oral diabetes and help control blood sugar levels. This medication decreases glucose production in the liver and also ensures that the intestines absorb less glucose. Saxagliptin on the other hand helps regulate the level of insulin that the human body is able to produce after a meal.
This combination of metformin and saxagliptin in Kombiglyze XR is prescribed by doctors for the treatment of type 2 diabetes. If you have symptoms of Type 2 diabetes and if the doctor prescribes the drug, you can buy Kombiglyze XR directly from a pharmacy.
Side effects of Kombiglyze XR
Several different side effects of Kombiglyze XR have been noticed during clinical trials. Some of the symptoms can be caused due to metformin in Kombiglyze XR, saxagliptin, or due to the combination of both. Some of the most common side effects include gas problems, headache accompanied by nausea and vomiting, indigestion, stomach pain followed by an upset stomach and diarrhea, a runny nose, infection in the upper respiratory tract, and a temporary metallic taste in the mouth.
Oral administration of Kombiglyze XR can also lead to severe side effects, some of which are allergic reactions and various symptoms of low blood sugar. Allergic reactions are very common and include rashes, itching skin leading to redness, difficulty breathing, hives, swelling of the face, tightness in the chest, and swelling of the lips and tongue. Some of the symptoms of low blood sugar seen in patients being administered with Kombiglyze XR include fast or rapid heartbeat, increase in hunger, headache and dizziness, anxiety, sweating, chills, tremors, and unexpected changes in vision. Fever and chills can be followed with persistent sore throat and muscle pain. Painful and frequent urination is also a severe side effect. If any of these symptoms persist, then it is advisable to consult a doctor.
It has been noticed through clinical trials that Saxagliptin in Kombiglyze XR can cause respiratory infection, infection in the urinary tract, sinusitis, and gastroenteritis.
Precautions
You can buy Kombiglyze XR once it has been prescribed, but at the same time, you need to take certain precautions as well. If you have a history of allergy to any form of metformin like Avandamet, Actoplus Met, Glucophage, Fortamet, and Riomet or saxagliptin like Onglyza, then you need to inform your doctor well in advance. If you are already seeking treatment for diabetic ketoacidosis or if you have kidney disease, it is important to consult your doctor before starting Kombiglyze XR treatment. Metformin in Kombiglyze XR can cause lactic acidosis, which can get worse over time and be fatal. If you notice any symptoms of lactic acidosis, stop taking Kombiglyze XR immediately and seek emergency medical help.
Kombiglyze XR Dosage
Kombiglyze XR is an oral medication and can be administered in three doses depending on a patient's requirement. It can be administered as Saxaglipitin 5mg / Metformin 500mg, Saxaglipitin 5mg / Metformin 1000mg, and Saxaglipitin 2.5mg / Metformin 500mg. Kombiglyze XR 5 mg/1000 mg tablets are pink in color, while 2.5 mg/1000 mg tablets are pale yellow in color, and they are both in the shape of capsules. The standard dose is Kombiglyze XR 5mg/500mg, which has to be administered once every day with the evening meal or dinner and needs to be swallowed whole. The doses can be adjusted based on the patient's tolerability and the drug’s effectiveness.
Interactions
Kombiglyze XR is not known to have any interactions, but it is advisable not to stop the medication or change the dosage without your doctor’s approval.
