Basic Information On Leukeran
Leukeran is a nitrogen-mustard alkylating-agent. It is a chemotherapy drug. It is used primarily for the treatment of malignant lymphomas (such as lymphosarcoma), leukemia (chronic lymphatic/lymphocytic leukemia), Hodgkin’s disease and giant-follicular lymphoma. It is used also used as an immuno-suppressant agent for several inflammatory conditions and auto-immune diseases like nephritic syndrome. The drug is not used as a cure for the above mentioned lymphomas or cancers. Brand or generic Leukeran works through several modes of action. It prevents the synthesis of DNA and transcription of RNA by affecting the DNA fragmentation. It forms cross-links and hence damages the DNA. This does not allow the damaged DNA to transcribe or synthesize. Lastly, the drug induces mutations by causing mis-pairing of certain nucleotides.
Precautions / Side Effects Of Leukeran
Less common side effects of Chlorambucil are changes on your skin like itching or rashes. You may sore or small ulcers in the mouth. The drug may also induce changes in the taste, which may remain until the treatment lasts. You may also have a risk of fits (or seizures) after starting the treatment. This is especially if you have had a prior history of fits or convulsions. Leukeran may also interfere with the normal liver function which may be temporary. If you have any of these less common side effects, then discuss with your doctor.
Brand or generic Leukeran may reduce the platelets production in the body. This may lead to easy bruising and/or bleeding, such as blood spots, bleeding gums etc. The drug lowers the RBC count in the body, resulting in anemia. After the treatment the drug may also cause nausea or vomiting. The drug may lead to lack of appetite also. After administering Chlorambucil if you have any of these side effects then get medical help as soon as possible.
Leukeran Dosage
Leukeran is administered orally in the form of tablets. The usual dose recommended for initiation of the treatment or for short-term treatment is 0.1 mg/kg to 0.2 mg/kg body weight. The drug is taken once a day for a period of 3-6 weeks. For an average patient the usual amount of drug needed is 4 mg to 10 mg in a day. The drug dosage should be adjusted carefully based on the individual patient’s response as well as the patient’s tolerability. The dose of Leukeran drug should be reduced immediately if the WBC counts or the platelet counts fall below normal.
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