Basic Information on Natulan
Natulan is an anti-neoplastic chemotherapy agent and belongs to the group of drugs called the alkylating agents. The drug is used in the management of cancer such as Hodgkin’s lymphoma. It is also used in the treatment Glioblastoma multiforme which is a form of brain cancer. The precise mechanism of action for this drug is not clear. However, it is suggested through some studies that the drug inhibits the transmethylation of methyl group into the t-RNA, thus leading to the absence of the t-RNA. The absence of this functional t-RNA may cease the synthesis of protein and therefore cease the synthesis of DNA and RNA. Additionally, the drug may damage the DNA directly. Thus the brand or generic Natulan acts by inhibiting the synthesis of protein, DNA and RNA.
Precautions / Side Effects for Natulan
Natulan shows its side effects on the central nervous system which include drowsiness, dizziness, confusion, headache, hallucinations, tremor, neuropathy, nightmares, depression, mania, syncope, psychosis, seizures, and paresthesia. Side effects related to hypersensitivity include rashes, photosensitivity, pruritus, and alopecia. Side effects on gastrointestinal tract are nausea, vomiting, ascites, stomatitis, anorexia, dry mouth, diarrhea, and dysphasia. Other side effects of procarbazine hydrochloride are cough, pulmonary effusion, anemia, hepatic dysfunction, thrombocytopenia, gynecomastia, gonadal suppression, photophobia, nystagmus, retinal hemorrhage, hypotension, edema, and tachycardia.
Natulan drug should be administered with caution if you have had a prior history of cardiovascular diseases, chronic illnesses, renal or hepatic impairment, psychiatric illness etc. Pregnant women and breast-feeding women must administer the drug with the physician’s advice. Seek your health care provider’s advice before administering the drug if you have received chemotherapy drugs or radiation therapy in the past. Elderly patients must administer the drug with caution and physician’s advice. Let your physician know about all the medications that you are currently taking as procarbazine hydrochloride shows drug-drug interactions.
Natulan Dosage
The starting dose of Natulan in pediatric population is recommended to be 50 mg/m2 of body surface, per day for the first week. The dose is then increased to 100 mg/m2 of body surface, per day. This dose is maintained until a maximum response is achieved or until the occurrence of either thrombocytopenia or leukopenia. The dose may be re-adjusted to 50 mg/m2 of body surface, per day once the maximum response is observed.
In adults the starting dose of brand or generic Natulan is 2-4 mg/kg/day during the first week of treatment. Thereafter the dose may be maintained at 4-6 mg/kg/day until a maximum response is achieved or until platelets <100,000/cmm or until WBC < 4000/cmm.
Buy Natulan from North Drug Store
North Drug Store provides the drug at a fixed dosage of 50 mg. Buy Natulan from our recognized mail order pharmacy and you can be sure of the confidentiality and quick service.
