Basic Information On Paraplatin
Paraplatin is a chemotherapy agent and is used primarily in the treatment of advanced ovarian cancer. It is also indicated for treating cancers of lung, neck and head. The drug slows down the growth of cancerous cells and prevents it from spreading in the body. Thus the drug interferes with the growth of cancerous cells. The drug contains alkylating agent which have 3 different mechanisms of action. Primarily, the drug prevents the RNA transcription and DNA synthesis from the DNA of the cancer cell. Secondly, the drug prevents the separation of DNA for its synthesis and its transcription. Lastly, the drug induces mis-pairing which in turn leads to mutations. These theories explain the mechanism of action for brand or generic Paraplatin.
Precautions / Side Effects For Paraplatin
Common side effects of Paraplatin may include loss of appetite, vomiting, nausea, feeling of tiredness, hair loss (temporarily) and swelling, reddening or pain at the site where the drug is injected. Inform your physician if these side effects prolong or worsen. You may experience certain allergic reactions such as difficulty in breathing, swelling in face, throat, lips or tongue and hives. Seek medical attention if you have any signs of these allergic reactions upon administering Carboplatin.
Serious side effects of brand or generic Paraplatin may include vision problem, hearing problem, changes to the skin at the site of injection, tingly feeling or numbness of feet or hands, ongoing/ severe vomiting, flu-like symptoms, body pain, fever, chills, sores in the throat or mouth, easy bruising, unexplained bleeding from the rectum, vagina, mouth or nose, pin-point spots appearing under the skin (red or purple in color), stomach pain, clay colored stools, darker urine and jaundice-like signs (eyes or skin becoming yellowish). Carboplatin may also cause low magnesium levels leading to confusion, uneven heart-rate, muscle weakness or jerking etc.
Paraplatin Dosage
When used as a single agent, the dosage of Paraplatin is 360 mg/m2. This is administered in form of an IV injection on day 1, once in 4 weeks. In a combination therapy the recommended dose of the drug is 300 mg/m2 administered IV on day 1, once in 4 weeks and for 6 cycles. 600 mg/m2 of Cyclophosphamide is administered IV on IV on day 1, once in 4 weeks, also for 6 cycles, alongside Paraplatin drug. Intermittent course of this combination therapy should be avoided till the platelet counts are 100,000 or more and the neutrophil counts are 2,000 or more.
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