Basic Information On Precedex
Precedex belongs to the class of drugs called hypnotics and sedatives. It is used as a sedative in patients who are on ventilator (mechanical or intubated ventilators) in the intensive care unit/setting (ICU). As a sedative the drug is used prior to surgery or during a surgery. The drug is a selective and specific agonist of alpha-2 adrenoceptor. Thus it acts by inhibiting the release of nor-epinephrine which helps in terminating the transmission of pain signal. Thus, it decreases the sympathetic tone. It has an analgesic and anxiolytic effect. This helps in minimizing the cardiovascular response during the peri-operative period. Brand or generic Precedex also reduces the analgesic, anesthetic and sedative needs of the patient while ensuring that respiratory depression is not caused.
Precautions / Side Effects For Precedex
Common side effects of Precedex include reduced salivation, sedation, decrease in heart rate, decrease in blood pressure and feeling tired. Other side effects of the drug include atrial fibrillation associated with irregular and faster heartbeat, fainting and dizziness. The drug may cause hypotension resulting in confusion, light headedness while sitting or lying position, dizziness, confusion and blurred vision. Bradycardia may occur with Dexmedetomidine along with slow heartbeat, unusual tiredness, light headedness and fainting or dizziness.
Dexmedetomidine may also cause hypoxia and bluish skin or lips. Less frequent side effects of the drug include anemia which is characterized by pale appearing skin, exertion, unexplained weakness or tiredness and trouble in breathing. You may also experience decreased urination, pleural effusion and pulmonary edema (characterized by noisy breathing, fast or difficult breathing, chest pain, wheezing, finger nails and lips turning bluish, pale skin, cough, shortness of breath and increased sweating.) Precedex drug may also cause abdominal pain, speech disorder, increased thirst and vomiting.
Precedex Dosage
When Precedex is used for the initiation of ICU sedation, the loading dose in adults is 1 mcg/kg, administered as infusion for 10-minutes. For the maintenance of ICU sedation the dose is 0.2-0.7 mcg/kg/h2our. For procedural sedation the initiation loading dose of brand or generic Precedex is 1 mcg/kg, administered as infusion over 10-minutes. However, the loading dose is 0.5 mcg/kg (over 10-minutes), for non-invasive or less invasive procedures (such as ophthalmic surgeries). The maintenance dose for procedural sedation is 0.6 mcg/ kg/ hour for adults. Based on the patient’s response and desired effect the dose may be adjusted between 0.2-1 mcg/kg/h2our.
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