Basic Information On Prograf
Prograf is a macrolide lactone that plays an important role in organ transplant. It belongs to a drug category of immunosuppressant. Being an immunosuppressive drug, it reduces the chances of organ rejection after vital organ transplants, such as allogeneic liver transplant, kidney transplant and heart transplant. In the treatment of severe refractory-uveitis, following a bone marrow transplant, vitiligo and eczema (severe atopic dermatitis), the drug is used topically. The drug decreases the production of interleukin-2 by the T-cells, which results in the immunosuppressive effect. Brand or generic Prograf acts by reducing the activity of the immune system, thus reducing the risk of rejection in any organ transplant. It has been demonstrated that the drug prolongs the existence of the transplanted graft and host, in organ transplant.
Precautions / Side Effect For Prograf
Common side effects of Prograf include, headache, insomnia, asthenia, blurred vision, tremor, paresthesia, delirium, peripheral edema, cardiac damage, hypertension, diarrhea, nausea, vomiting, constipation, ascites, abdominal pain, anorexia, kidney problems (nephrotoxicity), urinary tract infection, hematuria, albuminuria, proteinuria, anemia, hypomagnesemia, hyperglycemia, hypokalemia, back pain, dyspnea, rash, flushing, alopecia, pruritus, burning (with topical use, like cream or ointment), pain, chills, fever, itching, diabetes mellitus, depression, weakness, cramps and seizures. If any of the above mentioned side effects worsen or prolong with Tacrolimus, then consult your health care provider.
Other serious side effects may include renal failure, coma, leukocytosis, thrombocytopenia, hyperkaalemia, atelectasis, pleural effusion and anaphylaxis. Contact your health care provider immediately, if you experience any of the above mentioned serious side effects. The drug may also worsen any pre-existing fungal infection or any other infection, such as polyoma viral infection or herpes zoster. Tacrolimus should be avoided if you have hepatic diseases, infections and skin or lung cancer. Pregnant, breast-feeding women and infants should avoid the drug.
Prograf is administered IV by patients who are not able to take the drug orally and is administered only 6 hours after any transplantation. The initial dose is continuous IV of 0.03-0.05 mg/kg/day (kidney and liver) and 0.01 mg/kg/day (heart). Oral dosage for kidney transplant patients is 0.2 mg/kg/day in combination with azathioprine; 0.1 mg/kg/day with MMF/IL-2-antagonist; 0.10-0.15 mg/kg/day (adults) and 0.15-0.20 mg/kg/day (children) for liver transplant; 0.075 mg/kg/day for heart transplant (adults). 6 hours after a liver transplant, a patient is on IV and oral medication begins 2-3 days later. Oral medication of brand or generic Prograf begins only 8-12 hours after the IV infusion is stopped. The recommended capsule dosage is 0.10-0.15 mg/kg/day, every 12 hours (twice daily).
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