General Information on Prolopa Dispersible
Prolopa Dispersible, also known as Madopar Dispersible, is a drug whose common names are Levodopa and Benserazide. It is available as Prolopa Dispersible 50 mg/12.5 mg or Prolopa Dispersible 100 mg/25mg.
This drug is used to treat Parkinsonism – both idiopathic and encephalitic.
You can only buy Prolopa Dispersible as per a doctor’s prescription.
Side effects of Prolopa Dispersible
Prolopa Dispersible can sometimes lead to the following undesirable effects:
- Gastrointestinal – anorexia, nausea, vomiting, diarrhea and gastrointestinal bleeding
- Skin- allergic reactions
- Cardiovascular- cardiac arrhythmias as well as orthostatic hypotension
- Hematological- hemolytic anemia and transient leucopenia
- Neuropsychiatric- psychiatric disturbances are otherwise very common in patients suffering from Parkinson’s disease, which includes mild anxiety, insomnia, drowsiness, depression, hallucinations, and delusions
- Involuntary movements- choreiforma and oral dyskinesia are common in the case of long term administration of this drug. These are usually patients who are dose-dependent and become tolerable after dosage adjustments.
Dosage of Prolopa Dispersible
The recommended dose is one Prolopa Dispersible 50mg/12.5 mg tablet three to four times per day. If a patient is suffering from the advanced stage of the disease, then the dose should be one Prolopa Dispersible 100 mg/12.5 mg three times a day.
The daily dosage should be increased to one Prolopa Dispersible 100mg/25mg once or twice weekly until the total therapeutic effect is obtained. For elderly patients, a dose of Prolopa Dispersible 50mg/12.5mg once or twice daily should suffice. The dosage should be increased every third or fourth day.
The most effective dose will range from four to eight Prolopa Dispersible 100mg/25mg tablets or two to four Prolopa Dispersible 200 mg/50mg capsules daily in divided doses. Most patients will not need more than six Prolopa Dispersible 100mg/25mg tablets daily.
Treatment with Prolopa Dispersible should be continued for a minimum period of six months. Prolopa Dispersible 50mg/12.5mg tablets may be used to adjust the dosage as per the needs of the individual patient. Patients who experience fluctuations in response are asked to divide the dosage of Prolopa Dispersible 50mg/12.5mg into smaller and more frequent doses.
You may buy Prolopa Dispersible 200mg/50mg tablets for maintenance therapy once the optimal dose is determined with Prolopa Dispersible 100mg/25mg capsules.
An overdose of this drug may lead to cardiovascular side effects like cardiac arrhythmia or psychiatric disturbances like insomnia and confusion, gastrointestinal effects like nausea, or vomiting and abnormal/involuntary movements.
Interactions
Prolopa Dispersible can be taken along with anti-Parkinsonian agents such as anticholinergics, amantadine, and dopamine agonists. However, it may lead to the intensification of undesirable side effects. Therefore, the dosage of Prolopa Dispersible is to be reduced in such a case. When initiating adjuvant treatment for a Parkinson’s disease patient with CMOT inhibitors, the dose of the Prolopa Dispersible has to be reduced.
In case this drug is used with antihypertensive agents, it can lead to a hypotensive response, while sympathomimetics may elevate the cardiovascular side effects of Prolopa Dispersible.
Prolopa Dispersible is not to be used by pregnant women or those who are of a childbearing age/potential. If pregnancy occurs in the patient treated with this drug, the medication should be stopped immediately. Women taking Prolopa Dispersible should also not breastfeed their infants at this time.
