Basic Information On Sabril
Sabril belongs to the class of antiepileptic drugs and is prescribed for infants and for treating partial seizures in adolescents who are at least 16 years of age. Its use in infants is specifically meant for a condition called infantile spasms or West’s syndrome. The condition is also referred by several other terms. The treatment of this relatively uncommon condition is done only after carefully evaluation and consideration of the age of the infant. The cause of this condition is not known but it is speculated that it could be due to breakdown of the neurotransmitter GABA in the brain. The Sabril drug works by reversing this breakdown.
Side Effects/Precautions For Sabril
Sabril or Vigabatrin can cause vision problems. These problems may appear in a matter of weeks or may take years to develop. The decision to start on this medication is done only after considering the possible loss of vision. Often, the vision loss caused due to brand or generic Sabril is irreversible. It is essential to have regular eye tests and if any changes in vision occur, the dose may be changed or you may be taken off the drug. Apart from vision problems, you may also experience fatigue and numbness. Weight gain and memory problems are also reported.
Vigabartin may cause harm to an unborn baby. Pregnant women should not stop this drug despite possible injury to the fetus, unless instructed by the physician. Seizure control during pregnancy is essential for the well being of both mother and child. This drug is known to be excreted in human milk and can be passed through breastfeeding. Since it can cause mental deformities, a decision is often made to not breastfeed. Drugs that can interact with brand or generic Sabril include other antiepileptic, anti-inflammatory medication, anti depressants.
The recommended dosage of Sabril is 50 mg/kg/per day. The total daily dose can be given in two doses. If required, increments of 25 mg/kg/per day can be made once every 3 days. The total dose per day should not exceed 150 mg. The contents of the 500 mg packet should be dissolved in approximately 10 ml of cold water and then used. Since this drug is cleared by the kidneys, the efficiency of renal function also determines the dosage. It may not be prescribed if the infant has kidney problems either acquired or congenital. Young children and adults with renal impairment require dose adjustments. For mild impairment the dose needs to be reduced by 25%, for moderate it is 50% and for severe renal impaired it is 75 %.
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