Basic Information On Targretin
Targretin is used to treat cutaneous T-cell lymphoma. It works by regulating the expression of genes, which are responsible for the proliferation of cells, particularly those which have squamous characteristics. The final effect is preventing growth of cancerous tissue and its spread. The Targretin drug is used only when other modes of treatment, like chemotherapy, radiation or phototherapy have not been able to control symptoms satisfactorily.
Side Effects / Precautions For Targretin
Targretin or Bexarotene use in pregnant women can result in fetal defects and even fetal death. The drug should not be taken if you are pregnant or are planning to become pregnant. You will be required to take a pregnancy test, a week before the treatment starts, to confirm that you are not pregnant. Women are encouraged not to get pregnant during this treatment and to use adequate contraception during treatment, as pregnancy would halt treatment and this could worsen cancer symptoms, allowing the disease to metastasize. It also depletes an already weakened woman of resources that the body requires to recover.
Bexarotene causes side effects like increase in blood cholesterol, which could result in formation of plaques or blocks in arteries and eventually lead to a heart attack. Hence if you are prescribed brand or generic Targretin, your lipid profile will be monitored and analyzed on a regular basis. This drug also causes weakness and a numbing headache. Individuals receiving this drug are advised to avoid crowded places and sick people, in order to prevent infection. Skin side effects that are commonly reported include rash and itching. Many individuals also develop a dry skin, which can hurt. A good number of people receiving treatment also have thyroid problems, which can result in fatigue and weight loss.
Targretin Dosage
For treating cutaneous T cell lymphoma, the recommended dosage is 300 mg/m2 of body area per day. The administration of the drug and its effect are closely monitored for eight weeks. If desired tumor response has not been elicited, then the dose may be increased to 400 mg/m2/day provided the individual can tolerate the drug and toxicity levels are under control. However, if tumor response has been achieved or if the dose needs to be reduced, due to mounting toxicity levels, then dose adjustments are done in counts of 50 mg/m2/day: a daily dose of 200 mg/m2/day may be reduced to 100 mg/m2/day before stopping the use of this medication.
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