Basic Information On Vepesid
Vepesid is an anti-tumor or anti-neoplastic drug. It is a semi-synthetic drug and a podophyllotoxin derivative, that is used for treating neoplastic diseases. The drug is administered orally in form of soft gelatin capsules. It is also used in chemotherapy in certain cancers and malignancies like small cell lung cancer, lymphoma, testicular cancer, Ewing’s sarcoma, glioblastoma multiforme, and non lymphocytic leukemia. The drug acts by inhibiting the DNA synthesis during cell division (premitotic stage). This is achieved by inhibiting the DNA topoisomerase-II. These errors in the DNA synthesis lead to apoptosis of the tumor cells. The action of brand or generic Vepesid is phase- specific and depends on the cell cycle.
Precautions / Side Effects For Vepesid
Common side effects of brand or generic Vepesid include nausea, vomiting, allergic reactions, rashes, mouth sores, fever and acute myeloid leukemia. Fever is not caused due to any infection .It occurs soon after the drug is administered IV. If you are hypersensitive to any of the drug’s components, then avoid the administration of the drug. The drug might have drug-drug interactions when administered along with certain chemotherapeutic agents. Thus, before beginning the therapy with Etoposide, let your physician know if you are administering any other drug agents.
Serious side effects of Vepesid include (low blood pressure) hypotension, pain and/or burning sensation at the site, if administered IV, diarrhea, constipation, hair loss and metallic food taste. Check the blood pressure often while administering the drug especially if it is IV infusion. Side effects of the drug on the bone marrow are, decrease in the count of white blood cells which may result in the increase in susceptibility to various infections. Also, the effect of Etoposide on bone marrow results in reduced platelet count that leads to bleeding and bruising and reduced red blood count leading to anemia.
Vepesid Dosage
In the treatment of small cell lung cancer the dose of Vepesid should be rounded to 50 mg which should be administered in two divided doses. It is recommended that the drug is administered twice a day as 35 mg/m2/day, for a period of 4 days and then 50 mg/m2/day for another 5 days. When the drug is used in chemotherapy it is used as repeated courses at the intervals of 3 weeks to 4 weeks. Only 75% of the brand or generic Vepesid dose should be administered in patients with renal impairment and creatinine clearance of 15-50 ml/min.
Buy Vepesid From North Drug Store
Buy Vepesid at doses of 50 mg and 100 mg from our licensed Canadian pharmacy and be assured of confidentiality.
