Basic Information On Vidaza Injection
Vidaza Injection is used in the treatment of blood and bone marrow cancers like chronic myelomonocytic leukemia where there is an excessive production of immature red blood cells or refractory anemia and neutropenia. These disorders of the blood can also be caused by chemotherapy or could be primary i.e. not caused by other disorders. The Vidaza Injection drug has anti-neoplastic effect as it affects DNA through a process called methylation. The drug affects rapidly proliferating cells and non proliferating cells are not very sensitive to it.
Side Effects/Precautions For Vidaza Injection
When using Vidaza Injection or Azacitidine, most individuals notice a decrease in appetite and experience weight loss. Nausea may also persist. You will be pre- medicated for nausea before treatment begins. Diarrhea and constipation are other side effects that you may experience. If it becomes worse, your doctor may consider dose reductions. You may also notice formation of white patches or sores inside the mouth, which can be painful. Headache and joint pain are other side effects.
You must be careful when you are on treatment with Azacitidine as this drug can make you weak and prone to injury. You are also likely to bleed easily. If you are a woman, you would be advised against getting pregnant as brand or generic Vidaza injection is known to cause harm fetal harm. If you get pregnant, you must inform your doctor. Your doctor may suggest discontinuation of treatment. Liver and kidney disease may cause complications like toxic build up as the body is unable to clear the drug out of the system. Let your doctor know of any such conditions and medication that you may be taking for the same.
Vidaza Injection Dosage
The treatment is given in cycles and most individuals receive 4 to 6 cycles. During the first cycle, irrespective of an individual’s liver function, the dose is 75 mg/m2 administered subcutaneously or intravenously. During the following cycles, the dose may be increased to 100 mg/m2 if required. Patients should be closely monitored for toxic build up and dose increase should be considered if toxicity is negligible and effects of the drug are well tolerated. In elder patients, dose reduction is required due to reduced renal function. Dose adjustments are also required for those with renal or hepatic impairment from the second cycle onwards.
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