Buy Aggrenox from Canadian & International Pharmacies
Aggrenox (Dipyridamole/ASA)and/or alternatives
Basic Information On Aggrenox
Aggrenox is vasodilator and is used to decrease the risk of strokes in patients with prior history of transient ischemia in the brain. It is also effective in patients with thrombosis leading to ischemic stroke. The drug has multiple mechanisms of action. It acts by inhibiting thromboxane synthase which helps in reducing the effects of TXA2; these effects include bronchio-constriction, vaso-constriction and platelet aggression. It also blocks the reuptake of adenosine into the RBCs, endothelial cells and platelets, thus, it increases the concentration of extracellular adenosine. Also, it inhibits the breakdown of adenosine to inosine and increases the adenosine concentration. This increase of adenosine concentration in the coronary circulation causes vasodilatation. Brand or generic Aggrenox relaxes the arteriolar smooth muscles.
Precautions / Side Effects For Aggrenox
You may experience certain common side effects with Aggrenox drug which include joint pain, headache, drowsiness, stomach upset, nausea, vomiting, mild heartburn and diarrhea. Serious side effects of the drug may include fainting, weakness, coughing out blood, vomit that appears like coffee grounds, stools appearing black, tarry or bloody, swelling for more than 10 days, pain for more than 10 days, ringing in the ears, hearing problems, severe nausea or vomiting, severe stomach pain and fever for more than 3 days. Upon administering ASA/Dipyridamole if you experience these serious side effects then consult your physician immediately.
Brand or generic Aggrenox shows several drug-drug interactions with other class of drugs; for example, orally administered medication for diabetes, acetazolamide, medications for gout, ACE inhibitors, medications for Alzeimer’s disease, medications for seizures, diuretics, NSAIDs etc. Thus, let your doctor know about all the medications you are currently taking before administering ASA/Dipyridamole. Inform your doctor if you have prior history of liver or kidney disease, low blood pressure, heart diseases, bleeding disorder (like hemophilia) or stomach bleeding and/or ulcers.
The standard dose of Aggrenox is recommended as 1 capsule to be administered twice daily. The drug is administered orally, one dose in the morning and second dose in the evening. The dose may be adjusted based on the patient’s response and tolerability. If the signs of intolerance are seen, such as headaches, then the dose is reduced to only 1 capsule a day. This one capsule is to be administered at bed time. Once these effects subside, the usual regimen of Aggrenox drug must be continued. Any dose changes must be done with the advice of the health care provider.
Buy Aggrenox From North Drug Store
Buy Aggrenox at a fixed dosage of 200/25 mg from North Drug Store and be assured of on time supply.
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What is a "Generic" medication/drug?
Generic drugs are medications that have the comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo comparative testing to ensure that they are the same as their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain comparable active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must be comparable in strength and dosage to the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically comparable. They may look different, and be called something different, but they are required to be have the same active ingredient.
How are Generic drugs tested to ensure quality and efficacy?
The two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.