Buy Letairis from Canadian & International Pharmacies
Letairis (Ambrisentan)and/or alternatives
Letairis 10mg from $83.33 USD/tabletLetairis 10mg
Marketed as Volibris in European Union
Manufactured by: GlaxoSmithKline UK Ltd
Product of United Kingdom. Shipped from United KingdomRxPrescription Required
Letairis (ambrisentan) is a prescription drug to treat pulmonary arterial hypertension (PAH), which is high blood pressure in the lung arteries. Women who are prescribed Letairis must not get pregnant or breastfeed, as ambrisentan can cause serious birth defects. You may also be prescribed Tadalafil as a companion drug.
The proceeding text is for informational purposes only. North Drugstore is an online Canadian and international prescription service that sources medication from dispensaries all over the world. We do not supply any medication without a prescription. Only your doctor or healthcare provider may prescribe Letairis or any other medication. If you have questions about your Letairis prescription, consult the product information or speak to your doctor.
About Pulmonary Arterial Hypertension
Pulmonary Arterial Hypertension causes high blood pressure, which the World Health Organization has categorized into four classes of severity, Class I being mild with no physical limitations, Class IV being severe without any ability to perform physical activities. Letairis is intended for people with WHO Group 1 PAH who experience Class II symptoms. If you think you have PAH, speak to your doctor. Left untreated, PAH can get worse. Your doctor will schedule a series of tests to determine the cause of your high blood pressure. These tests include:
- Chest x-ray
- Right heart catheterization
- Blood tests
It has been proven that when Letairis and Tadalafil are taken together, patients with PAH experienced greater benefits, such as doubling their ability to walk long distances, reducing their chance of their PAH getting worse, and reduce rate of hospitalization for PAH. Taken alone Tadalafil is taken to treat pulmonary arterial hypertension to improve your capacity to exercise. Speak to your doctor about the benefits of pairing Letairis and Tadalafil.
Take your Letairis medication as directed. Letairis may react with other medications, so make sure to tell your doctor about other prescription drugs you are taking, including vitamins and herbal supplements. If you forget, take your Letairis medication as soon as you remember. If it’s close to your next scheduled dose, skip the dose. Do not take a double dose to catch up. Do not take Letairis unless it was prescribed to you, even if you are experiencing similar symptoms to PAH. Discuss with your doctor what other measures you can take to lower your high blood pressure, such as certain lifestyle changes.
Important Safety Information about Letairis
The following is taken from the product’s official website and is not a complete list of safety information. For a full list, consult with your doctor or the product literature. Not all safety information regarding pregnancy is listed.
Letairis can cause serious birth defects if taken during pregnancy.
- Females must not be pregnant when they start taking Letairis or become pregnant while taking Letairis
- Females who are able to get pregnant must have a negative pregnancy test before starting Letairis, every month while taking Letairis, and 1 month after stopping Letairis. Your doctor will decide when to do the tests, and order the tests for you depending on your menstrual cycle
- Tell your doctor right away if you miss a menstrual period or think you may be pregnant
- Females can only receive Letairis through a restricted program called the Letairis Risk Evaluation and Mitigation (REMS) program. If you are a female who can get pregnant, you must talk to your doctor, understand the benefits and risks of Letairis, and agree to all of the instructions in the Letairis REMS program.
Do not take Letairis if:
- You are pregnant, plan to become pregnant, or become pregnant while taking Letairis. Letairis can cause serious birth defects. (See "What is the most important information I should know about Letairis?")
- You have Idiopathic Pulmonary Fibrosis (IPF)
What should I avoid while taking Letairis?
- Do not get pregnant. If you miss a menstrual period, or think you might be pregnant, call your doctor right away
- Do not breastfeed. It is not known if Letairis passes into your breast milk.
Possible Side Effects
This is not the full list of possible side effects. For a full list, consult the product literature or ask your doctor. According to the official Letairis website, Letairis can cause these side effects if taken alone, such as:
- Swelling of hands, legs, ankles, and feet (peripheral edema)
- Stuffy nose (nasal congestion)
- Low red blood cell levels (anemia)
- Indigestion (dyspepsia)
- Upper respiratory tract infection (bronchitis)
If taken with Tadalafil, the following side effects may occur:
- Swelling of hands, legs, ankles, and feet (peripheral edema)
- Stuffy nose (nasal congestion)
- Inflamed nasal passages (sinusitis)
- Hot flashes or getting red in the face (flushing)
More serious side effects can occur, such as:
- Swelling all over the body (fluid retention) can happen within weeks after starting Letairis. Tell your doctor right away if you have any unusual weight gain, tiredness, or trouble breathing while taking Letairis. These may be symptoms of a serious health problem. You may need to be treated with medicine or need to go to the hospital.
- Decreased sperm counts (fluid retention) can happen within weeks after starting Letairis. Tell your doctor right away if you have any unusual weight gain, tiredness, or trouble breathing while taking Letairis. These may be symptoms of a serious health problem. You may need to be treated with medicine or need to go to the hospital.
- Low red blood cell levels (anemia) can happen during the first weeks after starting Letairis. If this happens, you may need a blood transfusion. Your doctor will do blood tests to check your red blood cells before starting Letairis. Your doctor may also do these tests while you are taking Letairis.
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IMPORTANT DISCLAIMER: All medical content is supplied by a third party company who is independent from this web site. As such, this web site can not guarantee the reliability, accuracy, and /or medical efficacy of the information provided. In all circumstances, you should seek the advice of a health professional pertaining to drug, treatment and/or medical condition advice. Note that not all products are shipped by our contracted Canadian pharmacy. This website contracts with dispensaries around the world that ship products directly to our customers. Some of the jurisdiction include but are not limited to United Kingdom, Europe, Turkey, India, Canada, Vanuatu, Mauritius, and USA. The items within your order may be shipped from any one of these jurisdiction depending on the availability and cost of the products at the time you place your order. The products are sourced from these countries as well as others. Please note that the product appearance may vary from actual product received depending on availability.
What is a "Generic" medication/drug?
Generic drugs are medications that have the comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo comparative testing to ensure that they are the same as their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain comparable active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must be comparable in strength and dosage to the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically comparable. They may look different, and be called something different, but they are required to be have the same active ingredient.
How are Generic drugs tested to ensure quality and efficacy?
The two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.