Buy Pentasa from Canadian & International Pharmacies
Pentasa (Mesalamine)and/or alternatives
Basic Information On Pentasa
Pentasa is an anti-inflammatory drug which is sold as controlled-release capsule, meant for oral route of administration. The drug is used for the treatment of ulcerative colitis which is mild to moderate in severity. Thus it is used to cure the inflammations of the digestive-tract. It is also used for remission induction. It is an amino-salicylate drug which particularly has its action on the gut and bowels. Therefore, the drug has certain systemic side-effects also. The drug is also indicated for Crohn’s disease which is mild to moderate in severity. The salicylic acid component of brand or generic Pentasa is an anti-oxidant. The drug acts by inhibiting the production of prostaglandin and blocking cyclo-oxygenase in the colon which results in diminishing the inflammation.
Precautions / Side Effects Of Pentasa
The common and expected side effects of Pentasa include flatulence, nausea, diarrhea and cramps. You may experience uncommon side effects with the drug which may include exacerbation of colitis, intestinal nephritis, hair loss, bleeding, bruising, sore throat, fever, malaise and headache. Uncommon side effects of Mesalamine/5-Aminosalicyclic Acid also include hypersensitivity reactions such as uritcaria, hives and rashes. If you experience the above mentioned uncommon side effects or the common side effects worsen, then consult your physician.
Rare side effects of Pentasa drug include blood disorders such as leucopenia, agranulocytosis, aplastic anemia, thrombocytopenia and neutropenia. Other rare side effects include hepatitis, acute pancreatitis and nephrotic syndrome. The mesalamine component of Pentasa has additional side effects (which are rare) such as allergic myocarditis, allergic lung reactions and methaemoglobinaemia. As mentioned above Mesalamine/5-Aminosalicyclic Acid has its side effects on the liver, kidney and blood. Patients with hepatic or renal impairment or blood disorders should administer the drug with caution and with physician’s advice.
Ulcerative colitis that is mild to moderate in severity is treated symptomatically. The recommended dose of Pentasa in the treatment of active ulcerative colitis and induction of remission is 1 g to be administered four times a day, which is a total dose of 4 g per day. This means either 2 Pentasa of 500 mg capsules or 4 Pentasa of 250 mg capsules each day. The recommended duration of the treatment is up to a period of 8 weeks. Also, it is recommended that blood tests should be done before and after the treatment with the brand or generic Pentasa.
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Buy Pentasa from our recognized mail order pharmacy at doses of 250 mg and 500 mg in varied quantities and be assured of our quick service.
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What is a "Generic" medication/drug?
Generic drugs are medications that have the comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo comparative testing to ensure that they are the same as their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain comparable active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must be comparable in strength and dosage to the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically comparable. They may look different, and be called something different, but they are required to be have the same active ingredient.
How are Generic drugs tested to ensure quality and efficacy?
The two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.