Buy Twynsta from Canadian & International Pharmacies
Twynsta (Amlodipine Besylate/Telmisartan)and/or alternatives
Basic Information On Twynsta
Twynsta is a combination drug which is di-hydropyridine calcium-channel blocker (DHP-CCB) and angiotensin-II receptor blocker (ARB). The drug is used in the treatment and management of hypertension. It is used in patients who are likely to be on a combination therapy (use of more than 1 anti-hypertensive agent) as an initial therapy, to achieve the desired blood pressure level. It may be used as a single therapy or in combination with several other anti-hypertensive drugs. The ARB component of brand or generic Twynsta acts by blocking the vasoconstriction effect of angiotensin-II receptor. The DHP-CCB acts by inhibiting the calcium ions influx into the cardiac muscles and vascular smooth muscles. This action blocks the calcium-ion induced contractile effect on the muscles. Thus, the drug brings about an anti-hypertensive effect.
Precautions / Side Effects Twynsta
You may experience certain common side effects of Twynsta such as headache, dizziness, diarrhea, stuffy nose, back pain and sore throat. Serious side effects of the drug are feeling like passing out, chest pain, heaviness in the chest, nausea, pain that spreads towards the shoulder or arm, sweating, no urination or less urination, slow/ fast heartbeat, muscle weakness, weak pulse and tingly feeling. Telmisartan/Amlodipine may also cause jaundice-like symptoms such as yellowish appearing of the eyes or skin. Inform your doctor if you experience any of these serious side effects upon administering the drug.
Twynsta drug may also cause allergic reactions such as swelling of the throat, tongue, face or lips, hives and difficulty in breathing. Also the drug may cause breakdown of the skeletal muscle tissues which may lead to kidney failure. Seek immediate medical attention if you experience any of these side effects. Also inform your doctor if you have muscle tenderness, muscle weakness, fever or dark color urine upon administering Telmisartan/Amlodipine.
The dosage of Twynsta is determined on an individual patient’s basis. It may differ from patient to patient. The recommended dose of the drug is 80/10 mg, to be administered daily once. However, usually the dose of Telmisartan is effective at 20 mg to 80 mg, when administered once daily. Also, the effective dose of Amlodipine is 2.5 mg to 10 mg per day. Based on an individual patient’s response and tolerability the dose of brand or generic Twynsta may be increased, but only 2 weeks after initiating the treatment. This is because any anti-hypertensive drugs show the effect within the first 2 weeks of treatment.
Buy Twynsta From North Drug Store
The drug is available at a fixed dosage of 40/5 mg with North Drug Store, our recognized mail order pharmacy. Buy Twynsta now and benefit from the quick service.
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What is a "Generic" medication/drug?
Generic drugs are medications that have the comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo comparative testing to ensure that they are the same as their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain comparable active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must be comparable in strength and dosage to the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically comparable. They may look different, and be called something different, but they are required to be have the same active ingredient.
How are Generic drugs tested to ensure quality and efficacy?
The two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.