Buy Bonefos from Canadian & International Pharmacies
Bonefos (Disodium Clodronate)and/or alternatives
Bonefos 400mg from $2.52 USD/capsuleBonefos 400mg
Manufactured by: Bayer Schering Pharma
Product of United Kingdom. Shipped from United KingdomRxPrescription Required
Bonefos 800mg from $4.92 USD/tabletBonefos 800mg
Manufactured by: Er-Kim Ilac
Product of TurkeyRxPrescription RequiredCurrently Unavailable
Basic Information On Bonefos
Bonefos is a bone resorption inhibitor as well as an antihypercalcemic agent that is used to treat osteolysis and hypercalcemia. Clodronate, one of the components in Bonefos, is a bisphosphonates and works by binding to hydroxyapatite. In vitro calcium crystals development and dissolution is inhibited. It prevents bone absorption as well as calcification of soft tissues. It can block cells which re-absorb bones. However, it does not affect bone strengthening cells. It is used to treat patients who have problems in their bones. The Bonefos drug prevents the breakup of calcium crystals thereby preventing calcification of soft tissue.
Precautions/Side Effects For Bonefos
Bonefos contains disodium clodronate. This drug has a few side effects which are very mild. Hence it is a relatively safe drug. Possible side effects of brand or generic Bonefos include nausea, indigestion, itching, rashes and diarrhea. However, if you experiences serious symptoms, you should consult the medical practitioner immediately. The doctor can reduce dosage to deal with the side effects or prescribe alternate medicines.
Since disodium clodronate reduces the amount of calcium in the body, it is recommended that one goes for regular blood tests when taking the drug. People with renal problems or inflammatory bowel disease should take this drug under strict medical supervision. Patients taking anti-inflammatory drugs should also let their medical practitioner know about the same when this drug is prescribed. Pregnant women should not consume brand or generic bonefos as its effect on the fetus has not been studied completely.
Bonefos is administered orally as a 400mg tablet once a day. It should not be taken with milk. Food should not be consumed for an hour before and after taking the drug. For I.V. infusion, the drug should be mixed with 500 ml of 0.9% sodium chloride injection. Alternatively, it may be mixed with 5% dextrose injection. For capsules, the maximum recommended daily dose is 8 capsules or 3200 mg. You should follow your doctor’s recommendation for the dosage. The recommended dosage is lower for patients suffering from severe renal impairment. Consult your physician immediately in case of the over dosage.
Buy Bonefos From North Drug Store
North Drug Store supplies Bonefos as 400mg tablets. Buy Bonefos from North Drug Store because we offer fast shipping (7 to 10 business days) on all orders. If you do not have a doctor’s prescription, please let us know who your doctor is and we will take care of the rest.
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What is a "Generic" medication/drug?
Generic drugs are medications that have the comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo comparative testing to ensure that they are the same as their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain comparable active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must be comparable in strength and dosage to the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically comparable. They may look different, and be called something different, but they are required to be have the same active ingredient.
How are Generic drugs tested to ensure quality and efficacy?
The two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.