Buy Depakote from Canadian & International Pharmacies
Depakote (Divalproex Sodium)and/or alternatives
Depakote 125mg from $0.52 USD/tabletDepakote 125mg
Marketed as Epival in Canada
Manufactured by: Abbott Laboratories Ltd.
Product of Canada. Shipped from CanadaRxPrescription Required
Depakote 250mg from $0.45 USD/tabletDepakote 250mg
Manufactured by: Sanofi
Product of India. Shipped from IndiaRxPrescription Required
Depakote 500mg from $0.61 USD/tabletDepakote 500mg
Manufactured by: Aventis Pharma Inc.
Product of India. Shipped from IndiaRxPrescription Required
General Information on Depakote
Depakote is a seizure medication indicated for the treatment of disorders such as epilepsy and manic episodes of bipolar disorder. The generic name of Depakote is valproic acid, which is a histone deacetylase or HDAC inhibitor.
Depakote is effective as an anticonvulsant, as well as a mood stabilizer. Its active ingredient, valproic acid, affects the naturally produced chemicals that are linked to seizures.
In some cases, Depakote has been found to be effective in the treatment of schizophrenia and major depression. You can buy Depakote only if your doctor has specifically prescribed it for your condition.
Side effects of Depakote
Depakote can damage the liver. In rare cases, this medication has also been reported to cause life-threatening liver failure. The risk of this occurring is higher in children, and even more so if these children are taking other seizure medications. The risk of life-threatening side effects also increases if the patient suffers from a metabolic disorder or a mentally impairing brain disease. Examples of such diseases include multiple sclerosis, a serious brain infection or injury, or Creutzfeldt-Jacob disease.
Depakote is also known to cause dangerous inflammations in the pancreas (pancreatitis) in rare cases. This condition can occur suddenly, and is likely to occur even if you have been taking Depakote for years. You must not take the drug if you have a history of blood clotting disorder, brain disorder, coma, head injury, or urea cycle disorder. You may also not be able to buy Depakote if you suffer from liver disease.
Serious side effects of Depakote include confusion, unexplained weakness or fainting with vomiting, reduced or no urination, body aches, flu-like symptoms, blood in the urine, hallucinations, lack of coordination, double vision, and extreme drowsiness.
The mild side effects of Depakote include an unusual or unpleasant lingering taste in the mouth, stomach upset, vision changes, tremors, hair loss, changes in menstrual cycle or weight, and constipation/diarrhea.
Dosage of Depakote
Depakote is available as an orally administered tablet. There are three types of tablets, each with their own strength- the lavender colored tablets have a strength of Depakote 500mg, the peach colored ones are Depakote 250mg, and the salmon colored tablets have a strength of Depakote 125mg. The dosage and duration of treatment will be determined by your doctor, and you must follow his/her instructions even if it differs from the recommended dosage.
The daily recommended dose of Depakote depends on the condition being treated. For the treatment of manic episodes, the recommended starting dosage is 750mg per day. The maximum dose that can be given is 60mg per kg of weight.
For the treatment of complex partial seizures, Depakote is recommended to be given only for patients of or over the age of 10 years. The recommended daily dose for this condition is between 10 and 15mg per kg of weight.
Buy Depakote from North Drug Store
The North Drug Store offers generic and branded versions of Depakote in all the different dosage levels. You can also find other types medications for the treatment of other medical conditions.
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What is a "Generic" medication/drug?
Generic drugs are medications that have the comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo comparative testing to ensure that they are the same as their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain comparable active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must be comparable in strength and dosage to the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically comparable. They may look different, and be called something different, but they are required to be have the same active ingredient.
How are Generic drugs tested to ensure quality and efficacy?
The two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.