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Factive (Gemifloxacin Mesylate)

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Full information about Factive

Basic Information On Factive

Factive is a broad-spectrum antibiotic and belongs to fluoro-quinolone class of drugs. It is used in the treatment of various bacterial infections. The drug is used in the treatment of pneumonia (mild to moderate in severity) and chronic bronchitis which is caused due to acute exacerbation of the bacteria. It is effective against S. pneumoniae, Moraxella catarrhalis, Haemophilus parainfluenzae and Haemophilus influenza strains. The drug is also effective in the treatment of pneumonia (mild to moderate in severity) which is community acquired and caused by the strains mentioned above as well as Chlamydia pneumoniae, Mycoplasma pneumoniae and Klebsiella pneumoniae. Brand or generic Factive acts by inhibiting the enzymes topoisomerase-II and IV responsible for DNA replication, recombination, repair and transcription of bacteria. Thus the drug blocks the bacterial growth.

Precautions /Side Effects For Factive

Common side effects of Factive are nausea, diarrhea, drowsiness, stomach upset, dizziness, loss of appetite, headache, altered taste, dry mouth, constipation and troubled sleeping. Serious side effects of Gemifloxacin are swelling or pain of joints, muscles and tendon, tendon rupture, sun burn (sensitivity to sun), vision changes, chest pain, dark urine, variations in the volume/amount of urine, easy bleeding, easy bruising, fast heartbeat, irregular heartbeat, fainting, sore throat, seizures, fever, unexplained fatigue, persistent vomiting or nausea and skin or eyes appearing yellow. Serious side effects of Factive drug also include mood changes or mental changes for example severe depression, suicidal thoughts etc.

If you experience these serious side effects then consult your physician immediately. If you use Gemifloxacin for a long period of time then you may experience new vaginal or oral fungal infections. You may experience vaginal discharge or patches in the mouth. In this case seek medical attention. Also report the serious allergic reactions such as hives, itching etc to your doctor.

Factive Dosage

The standard recommended dose of Factive is 320 mg per day. In the treatment of chronic bronchitis due to acute bacterial-exacerbation the dose is 320 mg tablet daily once, for 5-days. In the treatment of community-acquired pneumonia (mild to moderate) for strains K. pneumoniae and M. catarrhalis 320 mg tablet is taken once daily for 7-days and for any other strains it is taken for 5-days. For patients with creatinine clearance < 40 mL/min the recommended dose is 160 mg administered every 24 hours. The dose regimen of brand or generic Factive is determined based on sputum culture done prior to the therapy.

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