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Kemadrin (Procyclidine Hydrochloride)

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Full information about Kemadrin

General Information on Kemadrin

Kemadrin is indicated for the treatment of Parkinson's disease. It is also used to manage extrapyramidal side effects (such as involuntary body and face movements, restlessness or tremors) caused by antipsychotic medications. The drug is not intended to cure Parkinson’s disease, but only to provide relief from some of its symptoms.

Procyclidine Hydrochloride, the main active ingredient in the medication belongs to a class of drugs known as anticholinergic. It prevents Acetylcholine (a neurotransmitter) from binding to brain cell receptors, which reduces the effect of Acetylcholine.

Normal muscle movements depend on balance of two neurotransmitters, Dopamine and Acetylcholine. People with Parkinson’s disease have low levels of Dopamine which creates an imbalance. Procyclidine Hydrochloride tries to restore the balance between neurotransmitters by blocking the effects of Acetylcholine.

Kemadrin is available in the form of a tablet. The drug is a prescription medication which means you should buy Kemadrin and use it only if your doctor has recommended it in your treatment.

Side effects of Kemadrin

Kemadrin may cause mild to severe side effects in some people. Red swollen gums, dry mouth, constipation, problems with memory and understanding, blurred vision, nausea, vomiting, anxiety/nervousness/agitation, hallucinations, mental confusion, rashes, difficulty passing urine and disorientation are some side effects associated with Kemadrin.

The side effects mentioned above generally occur only when you take higher doses of Kemadrin. These side effects can be treated easily by lowering the dose. Kemadrin may also cause severe allergic reactions, such as a swollen mouth, face, throat, or lips, skin rashes, hives or itching. Consult your doctor immediately if you notice or experience side effects or allergic reactions after taking a dose of Kemadrin.

Pregnant women, women who plan to get pregnant, nursing mothers should learn about the risks and benefits associated with the drug before buying and using the medicine.

Dosage of Kemadrin

Your doctor will give you specific instructions regarding the dosage. Never take medication in larger quantity than recommended by your doctor. Each Kemadrin tablet contains 5mg of Procyclidine hydrochloride.

The recommended starting dose for adults with Parkinson’s disease is half tablet (equivalent to 2.5mg) three times a day. Doctor may increase the dose by 2.5mg to 5mg daily every 2-3 days until patients gets relief from Parkinson’s disease symptoms. Your doctor may recommend a long term dose of 15mg to 30mg daily to manage the symptoms.

The recommended starting dose to manage side effects of Neuroleptics medication in adults is 2.5mg, three times a day. Doctor may increase the dosage by 2.5mg each day until patient gets relief from the symptoms. The long term effective dose to manage symptoms is in the range of 10mg-30mg daily.


If you are using other medicines then Kemadrin may potentially interact with them and cause side effects. It may interact with medications such as Monoamine oxidase inhibitors, Paroxetine, Phenothiazines, Neuroleptics, Antihistamines, medicines used to treat nausea and gastric reflux, Levodopa, Amantidine, Quinidine.

To reduce the risk of side effects due to drug interactions, tell doctor about every medication you are using before starting the treatment. Tell him/her about prescription medicines, over the counter drugs and herbal supplements you are using before you buy Kemadrin tablets.

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