Buy Lariam from Canadian & International Pharmacies
Lariam (Mefloquine Hydrochloride)and/or alternatives
Lariam 250mg from $4.58 USD/tabletLariam 250mg
Manufactured by: Roche Products Ltd
Product of United Kingdom. Shipped from United KingdomRxPrescription Required
Mefloquine Hydrochloride 250mg from $3.17 USD/tabletMefloquine Hydrochloride 250mg
Generic Alternative to Lariam
Marketed as Meflotas in India
Manufactured by: Intas
Product of India. Shipped from IndiaRxPrescription Required
Mefloquine Hydrochloride 250mg is also available from CanadaMefloquine Hydrochloride 250mg from $6.13 USD/tabletMefloquine Hydrochloride 250mg
Generic Alternative to Lariam
Marketed as Apo-Mefloquine in Canada
Manufactured by: Apotex Inc.
Product of Canada. Shipped from CanadaRxPrescription Required
General Information on Lariam
Mefloquine Hydrochloride is the generic name for Lariam and it is orally administered for treatment of Malaria. It acts as a blood schizonticide and although its mechanism of action is unknown; it is used for treatment as well as prevention of Malaria. Mefloquine attacks malarial parasites once they are in the red blood cells. The inactive ingredients in Lariam include microcrystalline cellulose, ammonium-calcium alginate, Lactose, corn starch, crospovidone, tacl, poloxamer #331, and magnesium stearate. You can buy Lariam only if you have been diagnosed with Malaria or if it has been prescribed by your doctor.
Side effects of Lariam
The administration of Lariam can have mild to severe side effects on adults of all ages. Clinical trials have proven that administration of Lariam can cause different types of psychiatric side effects. Some of these side effects include sudden mood changes, depression, anxiety; sudden behavior changes, elevated emotion followed by crying, feelings of persecution, forgetfulness, confusion, aggression, hallucination, and constantly agitated state of mind. If you see any of these side effects or the symptoms, you should stop your medication and consult a doctor. These side effects of their symptoms have been noticed only after the third dose.
Some of the most common side effects of Lariam medication include nausea followed by vomiting, stomach pain followed by diarrhea, loss of appetite, fatigue, chills and fever, tinnitus, Myalgia, and swelling of lips and face.
There are certain precautions that you need to take before you start Lariam medication. Lariam can induce severe epileptic seizures, so you must consult your doctor if you have epilepsy. Since it impairs physical and mental ability, you are advised not to drive or operate heavy machinery during the period of Lariam treatment. Overdose and under dose can both be harmful and it is not recommended for children under 3 months or those who weigh less than 5kg. The safety of Lariam medication during pregnancy has not been established and hence most doctors recommend using effective contraception’s to prevent pregnancy during the period of medication. It is also not recommended for those who are suffering from kidney function failure, heart conduction defects, women who are breastfeeding, people who have history of convulsions, those with history of psychiatric illness including depression, and those suffering from decreased liver function.
The standard dosage is Lariam 250mg tablet once a week for patients weighing over 45kg. The administration of the medication normally starts 1 week prior to the arrival of the patient in an endemic area. The starting dose has to be followed up with weekly doses after the main meal and preferably at the same time of the day each week. Doctors advise that this tablet should not be taken on empty stomach and should be administered with at least 240 ml or 8 oz of water. The Lariam dosage for pediatric patients or those suffering from mild to moderate malaria is 2 doses of Lariam 250mg tablet taken after every 6-8 hours. Patients weighing between 30kg and 45kg should be administered with 3/4 tablet and those weighing between 20kg and 30kg should be administered 1/2 tablet. You can buy Lariam 250mg tablets from any reputable pharmacy.
Although drug-drug interactions of Lariam has not been noticed; doctors advise it should not be taken with beta blockers or with other malarial medication like quinidine, quinine, and chloroquine.
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What is a "Generic" medication/drug?
Generic drugs are medications that have the comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo comparative testing to ensure that they are the same as their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain comparable active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must be comparable in strength and dosage to the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically comparable. They may look different, and be called something different, but they are required to be have the same active ingredient.
How are Generic drugs tested to ensure quality and efficacy?
The two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.