Letairis (Ambrisentan)

Letairis

Letairis (ambrisentan) is a prescription drug to treat pulmonary arterial hypertension (PAH), which is high blood pressure in the lung arteries. Women who are prescribed Letairis must not get pregnant or breastfeed, as ambrisentan can cause serious birth defects. You may also be prescribed Tadalafil as a companion drug.

The proceeding text is for informational purposes only. North Drugstore is an online Canadian and international prescription service that sources medication from dispensaries all over the world. We do not supply any medication without a prescription. Only your doctor or healthcare provider may prescribe Letairis or any other medication. If you have questions about your Letairis prescription, consult the product information or speak to your doctor.

About Pulmonary Arterial Hypertension

Pulmonary Arterial Hypertension causes high blood pressure, which the World Health Organization has categorized into four classes of severity, Class I being mild with no physical limitations, Class IV being severe without any ability to perform physical activities. Letairis is intended for people with WHO Group 1 PAH who experience Class II symptoms. If you think you have PAH, speak to your doctor. Left untreated, PAH can get worse. Your doctor will schedule a series of tests to determine the cause of your high blood pressure. These tests include:

• Chest x-ray
• Echocardiogram
• Electrocardiogram
• Right heart catheterization
• Blood tests

About Letairis

It has been proven that when Letairis and Tadalafil are taken together, patients with PAH experienced greater benefits, such as doubling their ability to walk long distances, reducing their chance of their PAH getting worse, and reduce rate of hospitalization for PAH. Taken alone Tadalafil is taken to treat pulmonary arterial hypertension to improve your capacity to exercise. Speak to your doctor about the benefits of pairing Letairis and Tadalafil.

Take your Letairis medication as directed. Letairis may react with other medications, so make sure to tell your doctor about other prescription drugs you are taking, including vitamins and herbal supplements. If you forget, take your Letairis medication as soon as you remember. If it’s close to your next scheduled dose, skip the dose. Do not take a double dose to catch up. Do not take Letairis unless it was prescribed to you, even if you are experiencing similar symptoms to PAH. Discuss with your doctor what other measures you can take to lower your high blood pressure, such as certain lifestyle changes.

Important Safety Information about Letairis

The following is taken from the product’s official website and is not a complete list of safety information. For a full list, consult with your doctor or the product literature. Not all safety information regarding pregnancy is listed.

Letairis can cause serious birth defects if taken during pregnancy.

• Females must not be pregnant when they start taking Letairis or become pregnant while taking Letairis
• Females who are able to get pregnant must have a negative pregnancy test before starting Letairis, every month while taking Letairis, and 1 month after stopping Letairis. Your doctor will decide when to do the tests, and order the tests for you depending on your menstrual cycle
• Tell your doctor right away if you miss a menstrual period or think you may be pregnant
• Females can only receive Letairis through a restricted program called the Letairis Risk Evaluation and Mitigation (REMS) program. If you are a female who can get pregnant, you must talk to your doctor, understand the benefits and risks of Letairis, and agree to all of the instructions in the Letairis REMS program.

Do not take Letairis if:

• You are pregnant, plan to become pregnant, or become pregnant while taking Letairis. Letairis can cause serious birth defects. (See "What is the most important information I should know about Letairis?")
• You have Idiopathic Pulmonary Fibrosis (IPF)

What should I avoid while taking Letairis?

• Do not get pregnant. If you miss a menstrual period, or think you might be pregnant, call your doctor right away
• Do not breastfeed. It is not known if Letairis passes into your breast milk.

Possible Side Effects

This is not the full list of possible side effects. For a full list, consult the product literature or ask your doctor. According to the official Letairis website, Letairis can cause these side effects if taken alone, such as:

• Swelling of hands, legs, ankles, and feet (peripheral edema)
• Headache
• Stuffy nose (nasal congestion)
• Cough
• Low red blood cell levels (anemia)
• Indigestion (dyspepsia)
• Upper respiratory tract infection (bronchitis)

If taken with Tadalafil, the following side effects may occur:

• Swelling of hands, legs, ankles, and feet (peripheral edema)
• Stuffy nose (nasal congestion)
• Inflamed nasal passages (sinusitis)
• Hot flashes or getting red in the face (flushing)

More serious side effects can occur, such as:

• Swelling all over the body (fluid retention) can happen within weeks after starting Letairis. Tell your doctor right away if you have any unusual weight gain, tiredness, or trouble breathing while taking Letairis. These may be symptoms of a serious health problem. You may need to be treated with medicine or need to go to the hospital.
• Decreased sperm counts (fluid retention) can happen within weeks after starting Letairis. Tell your doctor right away if you have any unusual weight gain, tiredness, or trouble breathing while taking Letairis. These may be symptoms of a serious health problem. You may need to be treated with medicine or need to go to the hospital.
• Low red blood cell levels (anemia) can happen during the first weeks after starting Letairis. If this happens, you may need a blood transfusion. Your doctor will do blood tests to check your red blood cells before starting Letairis. Your doctor may also do these tests while you are taking Letairis.

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