Buy Metaglip from Canadian & International Pharmacies
Metaglip (Glipizide/Metformin Hydrochloride)and/or alternatives
Glipizide/Metformin Hydrochloride 2.5/500mg from $0.79 USD/tabletGlipizide/Metformin Hydrochloride 2.5/500mg
Manufactured by: A US FDA approved Generic Manufacturer
Product of United StatesRxPrescription RequiredCurrently Unavailable
General Information on Metaglip
Glipizide and Metformin are the active ingredients found in Metaglip. Glipizide is an anti-diabetic drug belonging to the sulfonylurea class while Metformin belongs to the biguanide class. Both are active ingredients of Metaglip and enable the treatment of Type 2 diabetes. You can buy Metaglip only if it has been prescribed by your healthcare provider and is normally prescribed along with exercise and controlled diet. Metaglip can be administered with other antidiabetic medication as well. The sulfonylurea in Metaglip, Glipizide, enables pancreas in your body to release insulin, which further helps in lowering the levels of blood sugar. Metformin, the biguanide, works by decreasing the amount of sugar produced in your liver and the amount absorbed by the intestine.
Side effects of Metaglip
Metaglip is known to cause mild side effects, which can sometimes become severe if left untreated. Some of the most common side effects of Metaglip include headache, indigestion and diarrhea, mild to severe stomach pain, nausea and vomiting, respiratory infection including sneezing, cough, sore throat, runny nose, and scratchy throat. Metaglip can also cause severe allergic reactions as well. Some of these symptoms include hives and rashes, and swelling of the face and mouth. Some of the other common side effects include lightheadedness, difficulty in breathing, feeling unusually cold, symptoms of low blood sugar like unusual sweating, fast heartbeat, and dizziness, blurred vision, anxiety, loss of appetite, dark urine, yellowing of skin, pale stool, back pain and discomfort among others.
There are certain precautions that you need to take before or after you buy Metaglip. It is always better to inform your doctor or healthcare provider if you have previously suffered an allergic reaction to Glipizide or Metformin, if you have low blood-oxygen levels, if you have had a heart attack recently, if you are going into surgery, if you have other medical problems like liver conditions and infection in the kidney. This medication is not recommended for adults over the age of 80 and pregnant women. You should consult your doctor if you are pregnant or are planning pregnancy or if you are breastfeeding. You should also consult your doctor prior to starting Metaglip course if you have a history of severe heart conditions, glucose-6-phosphate dehydrogenase (G6PD) deficiency or low level of blood calcium.
Metaglip is an oral medication that is available in the form of tablets that contain 2.5 mg glipizide and 250 mg metformin hydrochloride. You will also find Metaglip 2.5 mg glipizide and 500 mg metformin hydrochloride tablets as well. The standard dosage for patients with type 2 diabetes and unmanageable hyperglycemia is Metaglip 2.5 mg/250 mg once every day with lunch or dinner. If your FPG is between 280 mg/dL and 320 mg/dL then the recommended Metaglip dose will be 2.5 mg/500 mg twice a day. To achieve the right glycemic control, doctors prescribe Metaglip 10 mg/1000 mg once every day for 2 weeks.
Metaglip interacts with specific drugs like phenothiazines, corticosteroids, estrogen, thyroid products, oral contraceptives, nicotinic acid, phenytoin, sympathomimetics, and isoniazid. Inform your physician about all the medications that you are currently taking.
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What is a "Generic" medication/drug?
Generic drugs are medications that have the comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo comparative testing to ensure that they are the same as their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain comparable active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must be comparable in strength and dosage to the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically comparable. They may look different, and be called something different, but they are required to be have the same active ingredient.
How are Generic drugs tested to ensure quality and efficacy?
The two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.