Buy Migranal from Canadian & International Pharmacies
Migranal (Dihydroergotamine Mesylate)and/or alternatives
Basic Information On Migranal
Migranal is called ergot alkaloid also referred to as ergotamine which is a non-triptan preparation. It is 9, 10 alpha dihydro derivative. It is available in the form of a nasal spray. It is indicated in the treatment and management of headaches due to acute migraine, with aura or without aura. The drug is also used for the management of basilar migraine and as a prophylactic therapy for migraine. Brand or generic Migranal activates the 5-HT 1D receptors located at the sensory nerve-endings and inhibits the release of inflammation inducing neuropeptide. Secondly, the drug activates the 5-HT 1D receptors present on the intra-cranial blood vessels and induces vasoconstriction. These two actions of the drug correlate to the headache relief due to migraine.
Precautions / Side Effects For Migranal
Common side effects of Migranal are nose bleeding, stuffy nose, runny nose, nausea, vomiting and unpleasant or unusual taste in the mouth. It may also include pain, burning, numbness, dryness, irritation or tingling in the throat or nose. If these side effects prolong or worsen then consult your physician. Serious side effects of Dihydroergotaminemay include chest pain, uneven heart beat (slow or fast), muscular pain in the legs or arms, fainting, feeling light headedness and feeling cold, tingling or numbness in the toes and fingers.
Serious side effects of Dihydroergotaminemay may also include swelling/ pain/ weakness in the legs; headache or confusion occurring suddenly; sudden problems with speech, balance or vision, weakness/ numbness in the body (especially any one side); itching or swelling anywhere in the body. Pregnant and breast-feeding women must avoid the use of Migranal drug. Let your physician know if you have chest pain (angina), heart attack/ stroke, liver or kidney diseases, any infections, high blood pressure, arteriosclerosis, diabetes or high cholesterol in the past.
Migranal is administered as an intra-nasal drug and should not be used as an injection. The recommended dose of the nasal spray is 1 spray in each nostril. Each spray is equivalent to 0.5 mg of the drug. Another dose of 1 spray (or 0.5 mg drug) in each nostril is taken after a 15 minute interval. Thus a total dose of 4 sprays (that is 2.0 mg) of the drug is taken. The maximum recommended dose of brand or generic Migranal is 2.0 mg administered for a single migraine. A dose of 3.0 mg in a 24-hour period and 4.0 mg in 7-days time should not be exceeded.
Buy Migranal From North Drug Store
Buy Migranal nasal spray at 4 mg/ml dose from our recognized mail order pharmacy North Drug Store and get free refill reminder service.
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What is a "Generic" medication/drug?
Generic drugs are medications that have the comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo comparative testing to ensure that they are the same as their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain comparable active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must be comparable in strength and dosage to the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically comparable. They may look different, and be called something different, but they are required to be have the same active ingredient.
How are Generic drugs tested to ensure quality and efficacy?
The two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.