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Migranal (Dihydroergotamine Mesylate)

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Full information about Migranal

Basic Information On Migranal

Migranal is called ergot alkaloid also referred to as ergotamine which is a non-triptan preparation. It is 9, 10 alpha dihydro derivative. It is available in the form of a nasal spray. It is indicated in the treatment and management of headaches due to acute migraine, with aura or without aura. The drug is also used for the management of basilar migraine and as a prophylactic therapy for migraine. Brand or generic Migranal activates the 5-HT 1D receptors located at the sensory nerve-endings and inhibits the release of inflammation inducing neuropeptide. Secondly, the drug activates the 5-HT 1D receptors present on the intra-cranial blood vessels and induces vasoconstriction. These two actions of the drug correlate to the headache relief due to migraine.

Precautions / Side Effects For Migranal

Common side effects of Migranal are nose bleeding, stuffy nose, runny nose, nausea, vomiting and unpleasant or unusual taste in the mouth. It may also include pain, burning, numbness, dryness, irritation or tingling in the throat or nose. If these side effects prolong or worsen then consult your physician. Serious side effects of Dihydroergotaminemay include chest pain, uneven heart beat (slow or fast), muscular pain in the legs or arms, fainting, feeling light headedness and feeling cold, tingling or numbness in the toes and fingers.

Serious side effects of Dihydroergotaminemay may also include swelling/ pain/ weakness in the legs; headache or confusion occurring suddenly; sudden problems with speech, balance or vision, weakness/ numbness in the body (especially any one side); itching or swelling anywhere in the body. Pregnant and breast-feeding women must avoid the use of Migranal drug. Let your physician know if you have chest pain (angina), heart attack/ stroke, liver or kidney diseases, any infections, high blood pressure, arteriosclerosis, diabetes or high cholesterol in the past.

Migranal Dosage

Migranal is administered as an intra-nasal drug and should not be used as an injection. The recommended dose of the nasal spray is 1 spray in each nostril. Each spray is equivalent to 0.5 mg of the drug. Another dose of 1 spray (or 0.5 mg drug) in each nostril is taken after a 15 minute interval. Thus a total dose of 4 sprays (that is 2.0 mg) of the drug is taken. The maximum recommended dose of brand or generic Migranal is 2.0 mg administered for a single migraine. A dose of 3.0 mg in a 24-hour period and 4.0 mg in 7-days time should not be exceeded.

Buy Migranal From North Drug Store

Buy Migranal nasal spray at 4 mg/ml dose from our recognized mail order pharmacy North Drug Store and get free refill reminder service.

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