Buy Paludrine from Canadian & International Pharmacies
Paludrine (Proguanil Hydrochloride)and/or alternatives
Paludrine 100mg from $0.46 USD/tabletPaludrine 100mg
Manufactured by: AstraZeneca
Product of United Kingdom. Shipped from United KingdomRxPrescription Required
General Information about Paludrine
Paludrine is an anti-malarial medicine. Malaria is caused by a parasite called plasmodium that is passed onto human blood from mosquitoes. Once this parasite enters the blood stream, it multiplies inside the red blood cells and begins it attack on the human body. The active drug present in Paludrine is proguanil hydrochloride. It directly acts on the parasites by blocking an enzyme called ‘dihydrofolate reductase’, which is involved in the reproduction of the plasmodium parasite. As a result, the drug prevents the growth of the malarial parasite. Paludrine tablets are essentially preventive in nature. In certain parts of the world, the plasmodium parasite has grown resistant to proguanil. For these areas, you cannot buy Paludrine as an effective medicine.
Side effects of Paludrine
The reaction to any particular drug and the risk of side effects vary greatly from person to person. The following side effects of Paludrine are among the most common. Different reactions may occur for certain people due to certain factors, such as their age, health condition etc.
- problems in the stomach like constipation, diarrhoea, vomiting, nausea, abdominal pain ;
- loss of hair (reversible) ;
- angioedema ;
- ulcers in the mouth ;
- rashes and hives ;
- vasculitis or inflammation of blood vessels ;
Apart from the aforementioned side effects, a few people may experience an allergic reaction to this drug. Beside proguanil hydrochloride, Paludrine contains gelatin, magnesium stearate, calcium carbonate and maize starch. An allergic reaction can be triggered if you are allergic to any of the above ingredients in the drug. Malaria can be very dangerous when it occurs during pregnancy. It is best to avoid malaria prone sites while carrying a baby. The drug passes on to breast milk, so you must discuss the risks involved with your doctor before you begin taking this medication. People suffering from liver or kidney problems are at a greater risk of suffering from side effects due to Paludrine.
Paludrine is available in the form of 100mg tablets. The first dose of Paludrine should start at least two days (preferably a week) before you go to a malaria prone area. At least 2 days are needed to ensure that there are traces of proguanil in the blood to fight the parasite. Medication should continue throughout the stay (it is best to ingest the tablet at the same time every day) in the affected region, and until 4 weeks have passed from the time you leave the region. One tablet per day should be consumed with food and never on an empty stomach. Paludrine is most effective when taken with chloroquine, which is a drug that kills the plasmodium parasite. The tablets should not be stored at a temperature exceeding 30 degree Celsius.
Patients rarely buy Paludrine as the sole medication for the prevention of malaria. Often, it is taken along with chloroquine. Both these medications interact widely with other drugs.
Paludrine increases the effect of anticoagulants, so both these drugs must not be taken at the same time. Antacids reduce the capacity of the body to absorb proguanil from the stomach and hence should be taken (if required) at least 2 hours before Paludrine is taken. Medicines to treat indigestion should be discontinued for the period. Alcohol and certain types of food are not known to interact with Paludrine.
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What is a "Generic" medication/drug?
Generic drugs are medications that have the comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo comparative testing to ensure that they are the same as their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain comparable active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must be comparable in strength and dosage to the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically comparable. They may look different, and be called something different, but they are required to be have the same active ingredient.
How are Generic drugs tested to ensure quality and efficacy?
The two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.