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Paxil (Paroxetine Hydrochloride)

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Full information about Paxil

Basic Information of Paxil

The drug is an anti-depressant. It belongs to a category of drugs called selective serotonin reuptake inhibitor (SSRI). It is a derivative of phenylpiperidine. Paxil is used in the treatment and management of panic disorders, general anxiety disorder, social anxiety disorder (social phobia), obsessive compulsive disorder, major depressive disorder, pre-menstrual dysphoric disorder and post-traumatic stress disorder. It is sold as a prescription drug. The drug acts by inhibiting serotonin reuptake in the central nervous system. This in-turn has an anti-depressant, anti-panic and anti-obsessional effect. Brand or generic Paxil has long-term effects and is generally tolerated by most of the patients. The drug has broader therapeutic effects compared to other SSRIs. Thus, it is the only SSRI drug which is used for all the disorders mentioned above.

Precautions / Side Effects for Paxil

Common side effects with Paxil are sedation, dizziness, sleepiness, dry mouth, nausea, constipation, tremor and weight gain. It has sexual side effects such as delayed ejaculation in men and significant decrease in arousal, libido and duration of orgasm. Your physician or health care provider must be informed about any of the side effects that worsen. Other serious side effects of paroxetine include hypomania or mania; you must consult the physician if you experience any serious adverse effects with the drug.

Withdrawal of Paxil drug should be a gradual process as it may lead to discontinuation syndrome or withdrawal syndrome. The symptoms of discontinuation may include sensory disturbances, agitation, anxiety, nausea, confusion, sweating, diarrhea, emotional instability, visual disturbances, irritability, tremor, sleep disturbances, dizziness etc. Thus, constant monitoring is required while withdrawing the patient from the treatment. Pregnant women or women who are planning a pregnancy must avoid the administration of paroxetine as it may cause effects in the new born such as convulsions.

Paxil Dosage

In the treatment of major depressive disorder the starting dose of Paxil is recommended to be 20 mg/day and the maximum recommended dose is 50 mg/day. In the treatment of obsessive compulsive disorder the recommended starting dose is 20 mg/day and the maximum dose is 60 mg/day. In the management of panic disorder the starting dose is 10 mg/day and maximum dose is 60 mg/day. In the management of social anxiety disorder the starting dose is 20 mg/day and maximum dose is up to 60 mg/day. In patients with generalized anxiety and post-traumatic stress disorders the recommended dose range of brand or generic Paxil is 20-50 mg/day. Dose adjustments must be done based on individual patient’s response and with the doctor’s advice.

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