Buy Pennsaid from Canadian & International Pharmacies
Pennsaid (Diclofenac Sodium)and/or alternatives
Pennsaid 1.5% from $1.97 USD/mlPennsaid 1.5%
Manufactured by: Paladin Labs Inc.
Product of Canada. Shipped from CanadaRxPrescription RequiredCurrently Unavailable
Diclofenac Sodium 1.5% from $0.73 USD/mlDiclofenac Sodium 1.5%
Generic Alternative to Pennsaid
Marketed as Taro-Diclofenac in Canada
Manufactured by: Taro
Product of Canada. Shipped from CanadaRxPrescription Required
General Information on Pennsaid
Pennsaid is indicated in treatment of osteoarthritis of the knee(s). It is mainly used to provide relief caused by osteoarthritis of the knee. Diclofenac sodium, the main active ingredient in Pennsaid, belongs to a family of medicines known as non-steroidal anti-inflammatory drugs (NSAIDs).
Diclofenac works by blocking the action of cyclo-oxygenase, which plays an important role in the production of prostaglandins. Prostaglandins are natural substances that cause inflammation, swelling, and pain. They are made by the body to react to specific conditions, diseases, and injuries.
Pennsaid is available in the form of a topical solution. It is a prescription drug, which means you can not buy Pennsaid unless it is recommended by your doctor.
Side effects of Pennsaid
Pennsaid may cause mild to severe side effects in some people. Indigestion, heartburn, stomach upset, nausea, dry/scaly/thickened/itching/redness/burning/tingling sensation in the area where the medication is applied are some less serious side effects associated with Pennsaid. Consult your doctor if any side effects become bothersome or stay for a long time.
Some people may also experience severe side effects after taking a dose of Pennsaid. Bad breath, high blood pressure, redness/swelling of the eyes, rashes/sores/ulcers on the skin, unusual body odor, abnormal burning/pain/prickling sensation on the skin, stomach pain, or wheezing are some severe side effects associated with Pennsaid.
Pennsaid may also cause medical problems. You need to watch out for signs and symptoms that indicate medical problems such as-
- Signs of a liver problem – dark urine, itchy skin, pale stools, yellowing of the eyes or skin, abdominal pain.
- Signs of bladder or urinary tract infection - frequent urination, pain or burning sensation while passing urine, blood in the urine.
- Signs of sinus infection – tenderness or pain around the cheekbones or eyes.
- Signs of bleeding in the stomach – blood in the stools, coughing up of blood, dark colored vomit, dark or tarry stools.
- Signs of allergic reaction – difficulty breathing, swelling of the throat/face/tongue, difficulty breathing, hives.
Dosage of Pennsaid
Your doctor will give you specific instructions regarding the dosage. The recommended adult dose of Pennsaid is 40 drops of the medication on the knee, 4 times daily at even intervals, or 50 drops of the medication to the knee, 3 times daily at even intervals.
Apply the medication to the front, back and side of the knee. You should apply Pennsaid on clean and dry skin and not on infected or open skin.
Pennsaid may interact with other drugs you are using and cause side effects. It may interact with medicines such as Cyclosporine, lithium, medications for diabetes, bisphosphonates, Digoxin, Desmopressin, Fluoroquinolone antibiotics, medications for high blood pressure, medications/ herbal medications that affect blood clotting, Pemetrexed, Pentoxifylline, Sulfinpyrazone, Voriconazole, tricyclic antidepressants, NSAIDs, medications used to treat excessive acidity, intestinal/stomach ulcers, or reflux.
Inform your doctor about every drug you are using before you buy Pennsaid, including prescription drugs, over the counter medications, and herbal supplements.
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What is a "Generic" medication/drug?
Generic drugs are medications that have the comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo comparative testing to ensure that they are the same as their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain comparable active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must be comparable in strength and dosage to the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically comparable. They may look different, and be called something different, but they are required to be have the same active ingredient.
How are Generic drugs tested to ensure quality and efficacy?
The two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.