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Proglycem (Diazoxide)

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Full information about Proglycem

Basic Information On Proglycem

Proglycem is a peripheral vasodilator, which is a derivative of benzodiazepine. It is used to manage hypertensive emergencies. It is also used in the treatment of low blood sugar (hypoglycemia), which is caused due to hyper-insulinism. Hyper-insulinism may be due to various factors, such as, extra-pancreatic malignancy, non-operable islet-cell carcinoma/adenoma, islet-cell hyperplasia, leucine sensitivity and nesidioblastosis. The drug acts by inhibiting reabsorption of chlorine in the distal tubule. This increases the excretion of water, sodium, potassium and chloride. Thus, these actions put together, act on the smooth muscles and bring about an anti-hypertensive action. Brand or generic Proglycem also shows anti-hypoglycemic effect by slowing or inhibiting the release of insulin from the pancreas. This probably happens due to the opening of potassium channels into the membrane of beta cells.

Precautions / Side Effects For Proglycem

The common side effects of Proglycem include nausea, vomiting, loss of appetite, stomach pain, dizziness, headache, diarrhea, weakness, mild rashes or itching, anxiety and increased growth of hair on the body, especially on the arms, legs and forehead (temporarily). If any of these side effects prolong or worsen, then let your health care provider know. Serious side effects of Diazoxide include chest pain, pounding or rapid/fast heartbeat, unusual and extreme weakness, easy bleeding or bruising, frequent urination, breathlessness, swelling of feet or hands, sweating, eye pain, changes in the vision, itching or rashes of the skin, tingling of feet or hands, fever, body pain, flu-like symptoms, chills and the feeling of losing consciousness.

These serious side effects must be reported to your health care provider or physician, if you experience them upon administration of the drug. Before beginning the treatment with Proglycem drug, let your physician know if you have any of the following: gout, kidney disease, congestive heart failure, high triglycerides or cholesterol, hypokalemia (low potassium levels in the blood) or allergies. Pregnant and breast-feeding women must administer Diazoxide with caution.

Proglycem Dosage

In the treatment of hypoglycemia, the recommended dose of Proglycem in newborns and infants is 8-15 mg/kg that should be divided into 2 or 3 equal doses. The time interval between each dose should be 8-12 hours. The recommended starting dose is 10 mg/kg/day. The dosage in children and adults is 3-8 mg/kg and should be taken in 2-3 equal doses, every 8-12 hours. In the treatment of hypertension emergencies, the dose of brand or generic Proglycem is 1-3 mg/kg given IV in less than 30-seconds through the peripheral vein and a maximum dose of 150 mg should not be exceeded. The drug is given every 5-15 minutes initially and then every 4-24 hours.

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