Buy Purinethol from Canadian & International Pharmacies
Purinethol (Mercaptopurine)and/or alternatives
Purinethol 50mg from $6.08 USD/tabletPurinethol 50mg
Manufactured by: Teva
Product of Canada. Shipped from CanadaRxPrescription Required
Mercaptopurine 50mg from $0.67 USD/tabletMercaptopurine 50mg
Generic Alternative to Purinethol
Manufactured by: Zydus Cadila
Product of India. Shipped from IndiaRxPrescription Required
Basic Information On Purinethol
Purinethol is an anti-metabolite agent and anti-neoplastic drug. It is also an immunosuppressant agent. It is used in the treatment of acute lymphatic leukemia (lymphoblastic and lymphocytic). It is also used in the treatment of several other conditions such as polycythemia vera, non-Hodgkin’s lymphoma in the pediatric population, inflammatory bowel diseases (such as ulcerative colitis, Crohn’s disease etc.) and psoriatic arthritis. The drug acts by inhibiting the synthesis as well as metabolism of purine nucleotide. This in turn affects the synthesis as well as the function of DNA and RNA. The brand or generic Purinethol usually in combination with other agents interferes with the glycoprotein synthesis and the inter-conversion of nucleotides. This helps in the maintenance of program/therapy for leukemia.
Precautions / Side Effects For Purinethol
Common side effects of Purinethol include darkening of the skin, skin rashes, itching, headache, diarrhea, tiredness, weakness and skin or eyes becoming yellowish. Less common side effects of the drug include joint pain, swelling in the lower legs or feet, loss of appetite, nausea and vomiting. You may experience side effects other than the ones mentioned above, which are rare to occur. However, if you experience any of the above mentioned side effects then contact your health care provider. Rare side effects of Mercaptopurine may include sores on the lips or in the mouth.
You may experience other side effects of the drug which appear after the treatment with Purinethol drug is stopped. These side effects include tarry or black stools, blood in stools or urine, difficulty in urination, painful urination, yellowing of the eyes or skin, unusual bruising or bleeding, pin-point red color spots on the skin, lower-back pain or side pain, fever, chills, hoarseness and cough. Report these effects of Mercaptopurine to your physician.
Purinethol is recommended for the maintenance dose following a hematologic remission is achieved. The daily dose of the drug is recommended to be 1.5 mg/kg/day to 2.5 mg/kg/day as a maintenance dose. In pediatric population the when the drug is administered in combination with other agents (such as methotrexate) then better results are obtained in the treatment and remission of acute lymphatic leukemia. In patients with hepatic or renal impairment the treatment with brand or generic Purinethol should begin with lower doses. This is because the drug has great cumulative effect and it gets metabolized in the body and eliminated from the body slowly.
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What is a "Generic" medication/drug?
Generic drugs are medications that have the comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo comparative testing to ensure that they are the same as their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain comparable active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must be comparable in strength and dosage to the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically comparable. They may look different, and be called something different, but they are required to be have the same active ingredient.
How are Generic drugs tested to ensure quality and efficacy?
The two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.