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Rapamune (Sirolimus)

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Full information about Rapamune

Basic Information On Rapamune

Rapamune is and immunosuppressant drug; it lowers the effects of the immune system in the body. It is used as a prophylactic treatment for organ rejection in organ transplant, especially kidney transplant. The immune system helps the body to fight against any infections. Therefore, the same immune system can also fight against the transplanted organ and reject it. The drug acts by inhibiting the responses to the interleukin-2 (IL-2) which in-turn inhibits the B-cells and T-cells activation as well as proliferation. Thus, the cells do not complete the cell cycle and the progression from G1 to S phase of the cell cycle does not occur. Brand or generic Rapamune is preferred over other agents because its toxicity on the kidney is very low. Also, it can be used alone or in combination with other immunosuppressant agents.

Precautions / Side Effects For Rapamune

Some of the common side effects of Rapamune include joint pain, acne, skin rashes, headache, diarrhea, nausea, vomiting, stomach pain or constipation. Serious side effects of the drug include painful urination, burning sensation while urinating, shortness of breath, pain while breathing, chest pain, coughing out mucus or blood, weakness, feeling tired, faster heart rate, rapid weight gains, unexplained weight loss, night sweats, slow healing process of the wounds, swelling of feet, hands, face or stomach, flu-like symptoms, chills, fever, body pain, easy bruising, easy bleeding, pale skin or feeling like passing out. If you experience any of these side effects with Sirolimus seek medical help.

If you observe signs of any allergic reactions upon administering brand or generic Rapamune then let your physician know. These reactions may include difficulty in breathing, hives, swelling of throat, lips, tongue or face. Let your doctor know about any prior condition that you may have such as high cholesterol, high triglycerides, liver diseases, kidney diseases or cytomegalovirus (CMV). Pregnant and breast-feeding women should not administer Sirolimus without consulting their doctor.

Rapamune Dosage

Rapamune drug is administered in the form of oral solution or tablet. 2 mg of the oral solution is equivalent to 2 mg of tablet. The loading dose of the drug is calculated as 3 X (new/revised maintenance dose - the current maintenance dose). The dose adjustment is determined as current dosage X (target concentration/ current concentration). The maximum dose is recommended to be 40 mg per day. It is recommended that the initial dose of Rapamune should be taken soon after a transplant is done. Also, once a maintenance dose is determined, it should be continued for at least a period of 7-14 days.

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