Buy Sabril from Canadian & International Pharmacies
Sabril (Vigabatrin)and/or alternatives
Sabril 500mg from $1.26 USD/tabletSabril 500mg
Manufactured by: Sanofi Aventis
Product of United Kingdom. Shipped from United KingdomRxPrescription Required
Sabril 500mg is also available from CanadaSabril 500mg from $1.43 USD/tabletSabril 500mg
Manufactured by: Lundbeck Canada Inc
Product of Canada. Shipped from CanadaRxPrescription Required
Basic Information On Sabril
Sabril belongs to the class of antiepileptic drugs and is prescribed for infants and for treating partial seizures in adolescents who are at least 16 years of age. Its use in infants is specifically meant for a condition called infantile spasms or West’s syndrome. The condition is also referred by several other terms. The treatment of this relatively uncommon condition is done only after carefully evaluation and consideration of the age of the infant. The cause of this condition is not known but it is speculated that it could be due to breakdown of the neurotransmitter GABA in the brain. The Sabril drug works by reversing this breakdown.
Side Effects/Precautions For Sabril
Sabril or Vigabatrin can cause vision problems. These problems may appear in a matter of weeks or may take years to develop. The decision to start on this medication is done only after considering the possible loss of vision. Often, the vision loss caused due to brand or generic Sabril is irreversible. It is essential to have regular eye tests and if any changes in vision occur, the dose may be changed or you may be taken off the drug. Apart from vision problems, you may also experience fatigue and numbness. Weight gain and memory problems are also reported.
Vigabartin may cause harm to an unborn baby. Pregnant women should not stop this drug despite possible injury to the fetus, unless instructed by the physician. Seizure control during pregnancy is essential for the well being of both mother and child. This drug is known to be excreted in human milk and can be passed through breastfeeding. Since it can cause mental deformities, a decision is often made to not breastfeed. Drugs that can interact with brand or generic Sabril include other antiepileptic, anti-inflammatory medication, anti depressants.
The recommended dosage of Sabril is 50 mg/kg/per day. The total daily dose can be given in two doses. If required, increments of 25 mg/kg/per day can be made once every 3 days. The total dose per day should not exceed 150 mg. The contents of the 500 mg packet should be dissolved in approximately 10 ml of cold water and then used. Since this drug is cleared by the kidneys, the efficiency of renal function also determines the dosage. It may not be prescribed if the infant has kidney problems either acquired or congenital. Young children and adults with renal impairment require dose adjustments. For mild impairment the dose needs to be reduced by 25%, for moderate it is 50% and for severe renal impaired it is 75 %.
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What is a "Generic" medication/drug?
Generic drugs are medications that have the comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo comparative testing to ensure that they are the same as their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain comparable active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must be comparable in strength and dosage to the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically comparable. They may look different, and be called something different, but they are required to be have the same active ingredient.
How are Generic drugs tested to ensure quality and efficacy?
The two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.