Vytorin (Ezetimibe/Simvastatin)

Vytorin

Vytorin (ezetimibe and simvastatin) is a prescription drug that contains a cholesterol absorption inhibitor and an HMG-CoA reductase inhibitor (statin). It is intended to lower low-density lipoprotein (LDL) and increase high-density lipoprotein (HDL) for adults and children at least 10 years old who have high cholesterol. There is not yet any indication that Vytorin lowers your risk of heart disease.

The proceeding text is for informational purposes only. North Drugstore is an online Canadian and international prescription service that sources medication from dispensaries all over the world. We do not supply any medication without a prescription. Only your doctor or healthcare provider may prescribe Vytorin or any other medication. If you have questions about your Vytorin or generic Vytorin prescription, consult the product information or speak to your doctor.

About Vytorin

Avoid grapefruit juice and certain prescription drugs while taking Vytorin. Tell your doctor about all the medications, supplements, and vitamins you are taking. There are some health risks involved when taking Vytorin with other drugs, such as Colchicine, Lomitapide, Fenofibrate, fenofibric acid, Warfarin, Coumadin, Jantoven, Amiodarone, heart or blood pressure medicine or drugs containing niacin, or vitamin B3. Take only as directed by your doctor. Do not take Vytorin unless it was prescribed to you, even if you have high cholesterol. Tell your doctor if you have active liver disease, an abnormal liver function test, or are pregnant or nursing. If you forget to take a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip it. Do not take a double dose to catch up. If you overdose, seek medical attention immediately by calling poison control or visiting an emergency room.

Do not get pregnant while taking Vytorin. Speak to your doctor if you suspect that you are pregnant. Vytorin lowers “bad” cholesterol and increases “good” cholesterol. Avoid drinking alcohol or foods with high fat/cholesterol content. Vytorin works best in conjunction with these changes in diet. Speak to your doctor or dietitian about foods that are low in cholesterol.

Keep out of reach of children. Store at room temperature.

Important Safety Information

This is not a complete publication of Vytorin safety information. For a complete list, consult the product literature or speak to your doctor. According to the official Vytorin website, here are the following contraindications:

• Concomitant administration of strong CYP3A4 inhibitors (e.g., itraconazole, ketoconazole, posaconazole, voriconazole, HIV protease inhibitors, boceprevir, telaprevir, erythromycin, clarithromycin, telithromycin, nefazodone, and cobicistat-containing products).
• Concomitant administration of gemfibrozil, cyclosporine, or danazol. Hypersensitivity to any component of this medication. Active liver disease or unexplained persistent elevations in hepatic transaminase levels.
• Women who are pregnant or may become pregnant. Serum cholesterol and triglycerides increase during normal pregnancy, and cholesterol or cholesterol derivatives are essential for fetal development. Because HMG-CoA reductase inhibitors (statins), such as simvastatin, decrease cholesterol synthesis and possibly the synthesis of other biologically active substances derived from cholesterol, Vytorin may cause fetal harm when administered to a pregnant woman. Atherosclerosis is a chronic process and the discontinuation of lipid-lowering drugs during pregnancy should have little impact on the outcome of long-term therapy of primary hypercholesterolemia. There are no adequate and well-controlled studies of Vytorin use during pregnancy; however, in rare reports, congenital anomalies were observed following intrauterine exposure to statins. In rat and rabbit animal reproduction studies, simvastatin revealed no evidence of teratogenicity. Vytorin should be administered to women of childbearing age only when such patients are highly unlikely to conceive. If the patient becomes pregnant while taking this drug, Vytorin should be discontinued immediately and the patient should be apprised of the potential hazard to the fetus.
• Nursing mothers. It is not known whether simvastatin is excreted into human milk; however, a small amount of another drug in this class does pass into breast milk. Because statins have the potential for serious adverse reactions in nursing infants, women who require Vytorin treatment should not breastfeed their infants.

Patients should be advised of the increased risk of myopathy, including rhabdomyolysis, with the 10/80-mg dose. Patients should be advised to report promptly any unexplained and/or persistent muscle pain, tenderness, or weakness. Vytorin should be discontinued immediately if myopathy is diagnosed or suspected. Skeletal muscle effects (e.g., myopathy and rhabdomyolysis): Risks increase with higher doses and concomitant use of certain medicines. Predisposing factors include advanced age (≥65), female gender, uncontrolled hypothyroidism, and renal impairment. Rare cases of rhabdomyolysis with acute renal failure secondary to myoglobinuria have been reported. Liver enzyme abnormalities: Persistent elevations in hepatic transaminases can occur. Check liver enzyme tests before initiating.

Possible Side Effects

This is not a full list of side effects. To learn more about the possible side effects, refer to the product information or consult your doctor. According to the official Vytorin website, the possible side effects are:

• Headache
• Increased ALT
• Myalgia,
• Upper respiratory tract infection
• Diarrhea
• Myopathy/Rhabdomyolysis: Simvastatin occasionally causes myopathy manifested as muscle pain, tenderness or weakness with creatine kinase above ten times the upper limit of normal (ULN). Myopathy sometimes takes the form of rhabdomyolysis with or without acute renal failure secondary to myoglobinuria, and rare fatalities have occurred. The risk of myopathy is increased by high levels of statin activity in plasma. Predisposing factors for myopathy include advanced age (≥65 years), female gender, uncontrolled hypothyroidism, and renal impairment.

If you experience other side effects from taking Vytorin that is not listed here or in the product literature, you are encouraged to report them to your doctor.

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