Buy Prolopa CR from Canadian & International Pharmacies
Prolopa CR (Benserazide Hydrochloride/Levodopa)and/or alternatives
Prolopa 100/25mg from $0.55 USD/capsuleProlopa 100/25mg
Marketed as Madopar CR in European Union
Manufactured by: Roche Products Ltd
Product of United Kingdom. Shipped from United KingdomRxPrescription Required
General information on Prolopa CR
The drug Prolopa CR is used for treatment of Parkinsonism. The common names of the drug are Benserazide and Levodopa.
This drug helps in controlling Parkinsonism symptoms in patients by regulating the chemical imbalance in their brains. Levodopa only relieves symptoms of Parkinsonism however it does not slow down the progression of Parkinson's disease.
Levodopa can be taken alone. However, if taken with Benserazide it can curb side effects such as nausea and vomiting that are generally related with the use of Levodopa alone.
A patient should buy Prolopa CR only with a doctor's prescription. Besides, the capsules of Prolopa CR must not be opened prior to ingestion since it is a sustained release drug and will lose its characteristics.
Side effects of Prolopa CR
Some of the less serious side effects reported in some patients taking Prolopa CR are:
- Impairment or loss of voluntary activity
- Erratic breathing
- Swelling of the face, hands, lower legs or feet
- Impaired ability to think
- Lower back pain
- Trouble sleeping
- Unusual or excessive tiredness
A patients should seek immediate medical help if he/she exhibits the following severe side effects:
- Twitching and twisting
- Fearfulness or other mental changes
- Involuntary movement of the limbs and facial muscles
- Inability to move the eyes
- Agitation and delusion
- Sudden freezing and instability in posture
Dosage of Prolopa CR
The available strengths of Prolopa CR are: Prolopa CR 50-12.5 containing Benserazide 12.5 mg and Levodopa 50 mg; Prolopa CR 100-25 containing Benserazide 25 mg and Levodopa 100 mg; and Prolopa CR 200-50 containing Benserazide 50 mg and Levodopa 200 mg .
In the beginning, a low dose of Prolopa CR is given to a patients and is gradually increased to reduce side effects and help a patient attain maximum benefit of the drug.
The recommended dosage is one capsule of Levodopa 100 mg and Benserazide 25 mg one or two times a day. Doctors increase the dosage gradually by one capsule every third or fourth day until patients achieves the best results. When the dose is maintained, a doctor will elevate the dose at an interval of 15 days to 1 month. This dose should be divided so that a patient takes the medication at least four times a day soon after meals. The recommended dose Prolopa CR is 4 to 8 capsules of Benserazide 25 mg and Levodopa 100 mg a day divided into a minimum of four and maximum of six doses.
Patients who are allergic to Levodopa or Benserazide, are unable to take sympathomimetic amines like epinephrine and who have taken MAQ inhibitors like phenezine and trancylcypromine within 15 days of taking Levodopa or Benserazide should not take Prolopa CR. Patients with heart, lung, kidney or liver disease, narrow angle glaucoma, or a psychiatric disorder should avoid this drug. Women under the age of 25 years as well as pregnant women should avoid Prolopa CR.
Prolopa CR has interactions with many other drugs. The include tricyclic antidepressants such as amitriptyline and desipramine, sympathomimetic drugs such as epinephrine and trihexyphenidyl, ferrous sulphate, amantadine, selegiline, anesthetics, metoclopramide, pyridoxine, dopamine agonists and phenytoin.
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What is a "Generic" medication/drug?
Generic drugs are medications that have the comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo comparative testing to ensure that they are the same as their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain comparable active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must be comparable in strength and dosage to the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically comparable. They may look different, and be called something different, but they are required to be have the same active ingredient.
How are Generic drugs tested to ensure quality and efficacy?
The two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.