Buy Prolopa Dispersible from Canadian & International Pharmacies
Prolopa Dispersible (Benserazide Hydrochloride/Levodopa)and/or alternatives
Prolopa 100/25mg from $0.50 USD/tabletProlopa 100/25mg
Marketed as Madopar Dispersible Tablets in European Union
Manufactured by: Roche Products Ltd
Product of United Kingdom. Shipped from United KingdomRxPrescription Required
General Information on Prolopa Dispersible
Prolopa Dispersible, also known as Madopar Dispersible, is a drug whose common names are Levodopa and Benserazide. It is available as Prolopa Dispersible 50 mg/12.5 mg or Prolopa Dispersible 100 mg/25mg.
This drug is used to treat Parkinsonism – both idiopathic and encephalitic.
You can only buy Prolopa Dispersible as per a doctor’s prescription.
Side effects of Prolopa Dispersible
Prolopa Dispersible can sometimes lead to the following undesirable effects:
- Gastrointestinal – anorexia, nausea, vomiting, diarrhea and gastrointestinal bleeding
- Skin- allergic reactions
- Cardiovascular- cardiac arrhythmias as well as orthostatic hypotension
- Hematological- hemolytic anemia and transient leucopenia
- Neuropsychiatric- psychiatric disturbances are otherwise very common in patients suffering from Parkinson’s disease, which includes mild anxiety, insomnia, drowsiness, depression, hallucinations, and delusions
- Involuntary movements- choreiforma and oral dyskinesia are common in the case of long term administration of this drug. These are usually patients who are dose-dependent and become tolerable after dosage adjustments.
Dosage of Prolopa Dispersible
The recommended dose is one Prolopa Dispersible 50mg/12.5 mg tablet three to four times per day. If a patient is suffering from the advanced stage of the disease, then the dose should be one Prolopa Dispersible 100 mg/12.5 mg three times a day.
The daily dosage should be increased to one Prolopa Dispersible 100mg/25mg once or twice weekly until the total therapeutic effect is obtained. For elderly patients, a dose of Prolopa Dispersible 50mg/12.5mg once or twice daily should suffice. The dosage should be increased every third or fourth day.
The most effective dose will range from four to eight Prolopa Dispersible 100mg/25mg tablets or two to four Prolopa Dispersible 200 mg/50mg capsules daily in divided doses. Most patients will not need more than six Prolopa Dispersible 100mg/25mg tablets daily.
Treatment with Prolopa Dispersible should be continued for a minimum period of six months. Prolopa Dispersible 50mg/12.5mg tablets may be used to adjust the dosage as per the needs of the individual patient. Patients who experience fluctuations in response are asked to divide the dosage of Prolopa Dispersible 50mg/12.5mg into smaller and more frequent doses.
You may buy Prolopa Dispersible 200mg/50mg tablets for maintenance therapy once the optimal dose is determined with Prolopa Dispersible 100mg/25mg capsules.
An overdose of this drug may lead to cardiovascular side effects like cardiac arrhythmia or psychiatric disturbances like insomnia and confusion, gastrointestinal effects like nausea, or vomiting and abnormal/involuntary movements.
Prolopa Dispersible can be taken along with anti-Parkinsonian agents such as anticholinergics, amantadine, and dopamine agonists. However, it may lead to the intensification of undesirable side effects. Therefore, the dosage of Prolopa Dispersible is to be reduced in such a case. When initiating adjuvant treatment for a Parkinson’s disease patient with CMOT inhibitors, the dose of the Prolopa Dispersible has to be reduced.
In case this drug is used with antihypertensive agents, it can lead to a hypotensive response, while sympathomimetics may elevate the cardiovascular side effects of Prolopa Dispersible.
Prolopa Dispersible is not to be used by pregnant women or those who are of a childbearing age/potential. If pregnancy occurs in the patient treated with this drug, the medication should be stopped immediately. Women taking Prolopa Dispersible should also not breastfeed their infants at this time.
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What is a "Generic" medication/drug?
Generic drugs are medications that have the comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo comparative testing to ensure that they are the same as their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain comparable active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must be comparable in strength and dosage to the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically comparable. They may look different, and be called something different, but they are required to be have the same active ingredient.
How are Generic drugs tested to ensure quality and efficacy?
The two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.