Basic Information On Kuvan
An enzyme known as phenylalanine hydroxylase breaks the amino acid phenylalanine in the food as a part of digestion. If the process is not satisfactory due to a genetic condition (phenylketonuria or PKU), the phenylalanine Phe level in the blood increases and may cause behavioral problems. Some of the indications are decreased levels of intelligence, ability to concentrate, focusing and power of remembrance. Kuvan with its main ingredient sapropterin dihydrochloride acts with the PAH enzyme to lower Phe levels in the blood. Kuvan is the first prescription medicine meant for treating people for whom dietary management alone has not helped. Kuvan is to be taken along with recommended changes in the diet and regular monitoring of Phe level.
Precautions/Side Effects For Kuvan
Sapropterin dihydrochloride acts by stimulating the phenylalanine hydroxylase enzyme and planned management of your diet is essential during the entire treatment. Do not take brand or generic Kuvan without prescription. Mention all other medication that you are taking such as Levodopa and particularly those for controlling Folate metabolism or erectile dysfunction. Please report previous problems, if any, relating to kidneys or liver. Discuss other conditions like poor nutrition, pregnancy plans and breast feeding with your doctor. Get your Phe blood level regularly as advised by your doctor. The tablets may change to light yellow in color over time. This is normal. Store the tablets along with the supplied desiccant to prevent moisture. Do not store the tablets in hot conditions (bathroom cabinets or cars).
Some side effects may occur during the brand or generic Kuvan (sapropterin dihydrochloride) therapy. They are throat pain, nausea or vomiting, colds, abdominal pain or diarrhea. Sapropterin dihydrochloride may interfere with other drugs or food items; for example, herbal food supplements may interfere with Kuvan. Phe level may go up if you run fever. Should you notice any unusual discomfiture, discuss with the doctor or pharmacist.
The recommended dose of Kuvan to start with is 10 mg per kg of body weight per day. Dissolve one tablet in four ounces (half cup) or eight ounces (one cup) of water or apple juice. You may crush the tablet or stir to dissolve it faster. Take Kuvan with food for better absorption. Mix a little more water or apple juice and shake or stir the cup and swallow if any residue or small particles are left behind. Consume the solution within 15 minutes of preparation. Do not exceed or double the dose when you miss one. Follow the structured diet prescribed.
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We stock Kuvan tablets in 100 mg dosage. You will benefit substantially because of lower prices when you buy Kuvan from North Drug Store.