Basic Information On Truvada
Truvada is an anti-HIV medicine which belongs to the drug category called “nucleoside reverse transcriptase inhibitor”. It is used to treat HIV infection (human immunodeficiency virus). It is a combination of many antiviral medicines. The Truvada drug is always used in adjunct therapy with other anti-HIV drugs. It stops the HIV from changing the genetic material of healthy CD4 cells. It helps control the infection by slowing down the growth of HIV virus and decreasing the amount of existing virus. It is most effective when it is maintained at a constant level in the body. This medication is not a cure for HIV, nor does it prevent the HIV infection from passing onto others. It received approval by the U.S. Food and Drug Administration (FDA) for treating HIV, in August 2004.
Precautions / Side Effects Of Truvada
The active chemical ingredients in Truvada are Emtricitabine and Tenofovir Disoproxil Fumarate. It can cause common side effects like joint pains, dizziness, muscle pain, nausea, sleeping problems, inflammation of the liver and diarrhea. These side effects may indicate build up of acid in the blood. Brand or generic Truvada can also cause liver complications like hepatotoxicity, with liver enlargement (hepatomegaly), and fat in the liver (steatosis). These liver disorders are indicated by dark colored urine, light colored stools, and yellowing of skin or eyes. You should undergo regular blood tests to check your kidneys. Truvada may also change your body fat.
Emtricitabine and Tenofovir Disoproxil Fumarate can interact with other medications such as: ATRIPLA (efavirenz 600 mg/emtricitabine 200 mg/tenofovir DF 300 mg), EMTRIVA, Combivir (lamivudine/zidovudine), VIREAD, Epzicom (abacavir sulfate/lamivudine), Epiviror Epivir-HBV (lamivudine). These medications contain similar active ingredients as Truvada. Brand or generic Truvada should not be taken with HEPSERA (adefovir dipivoxil). This medication may also cause skin problems like spots and freckles.
Truvada Dosage
The recommended Truvada dosage is one 200/300 mg tablet taken daily. One tablet contains 200 mg of emtricitabine and 300 mg of tenofovir disoproxil fumarate. You can take it orally with or without food. You would need special dose adjustment if you have severe renal impairment, with baseline creatinine clearance 30-49 ml/min. In such a case, you should take one dose every 24 hours. Your response to this medication and your renal function should be carefully monitored by your doctor to gauge the efficacy of the treatment. However, if you have only mild renal impairment, with creatinine clearance 50-80 mL/min, you may take one tablet daily without any adjustment. Your calculated creatinine clearance and serum phosphorus should be monitored daily.
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