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Evamist (Estradiol)

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Full information about Evamist

General Information on Evamist

Evamist is a transdermal spray used to treat night sweats and hot flashes experienced by women going through menopause. It contains Estradiol, a form of estrogen.

Estradiol, the main active ingredient in the medication, acts as a hormone replacement. It binds itself to estrogen sensitive tissues and prevents the release of follicle stimulating hormone, luteinizing hormone, and gonadotropin through a negative feedback mechanism. These hormones may be linked to some menopause symptoms.

Evamist is available in the form of a skin spray. Each spray delivers 90mvL, which contains 1.53mg of Estradiol. The drug is a prescription medication, so you must consult a doctor before you buy Evamist.

Side effects of Evamist

Evamist may cause mild to severe side effects in some cases. Some women may experience nipple pain, joint pain, headaches, back pain, breast tenderness, or common cold after using Evamist. These are common side effects associated with the medication and wane over time. However, you should inform your doctor if any side effect persists or worsens.

Some women may also experience severe side effects after using Evamist. Heart attacks, depression, breast cancer, gallbladder disease, uterine cancer, strokes, ovarian cancer, or dementia are some severe side effects associated with the drug. Other severe side effects of Evamist include unexpected or heavy vaginal bleeding or allergic reactions such as difficulty swallowing or breathing, wheezing, or unexplained swelling.

Formation of blood clots is also one of the severe side effects associated with Evamist. You should always watch out for the following symptoms that indicate blood clots in specific parts of the body or other medical problems:

  • Signs of blood clot in the leg - Foot or leg swelling, leg cramps, pain in the calf region.
  • Signs of a blood clot in the lung – Sharp chest pain, shortness of breath, or coughing up of blood.
  • Signs of liver damage – Yellowing of the skin and eyes, pain in the upper right abdominal region, dark urine.
  • Signs of a stroke – Numbness or weakness in the leg or arm, speech or vision changes, severe headache.
  • Signs of blood clot in the eye- Vision changes, sudden loss of vision.

Dosage of Evamist

The dosage of Evamist depends on several factors such as your response to treatment, other medical conditions you are suffering from, and the severity of menopause symptoms. Your doctor will give you specific instructions regarding the dosage.

Doctors generally recommend a small dose of one spray which is equivalent to 1.53mg Estradiol at the beginning of treatment. Spray the medication on any area between the forearm and wrist. You need to ensure that the medication is only sprayed on dry, clean, and unbroken skin. Evamist should only be used once a day.

Evamist dries quickly after application, but you must wait for at least two minutes after spraying the drug before wearing any clothing on the sprayed area.


Evamist may interact with other drugs you are taking and cause side effects. It may interact with protease inhibitor HIV medications, barbiturates, Cyclosporine, Rifamycin antibiotics, some seizure medications, thyroid replacement medications, several antifungal medications, antibiotics, or St. John's Wort.

To reduce the risk of side effects, inform your doctor about the different medications you are using, which includes prescription medications, over the counter medicines, and herbal supplements before you buy Evamist.

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