Buy Kombiglyze XR from Canadian & International Pharmacies
Kombiglyze XR (Saxagliptin Hydrochloride/Metformin Hydrochloride)and/or alternatives
Kombiglyze XR 5/500mg from $2.60 USD/tabletKombiglyze XR 5/500mg
Manufactured by: Astra Zeneca
Product of India. Shipped from MauritiusRxPrescription Required
Kombiglyze XR 2.5/1000mg from $2.81 USD/tabletKombiglyze XR 2.5/1000mg
Manufactured by: Bristol-Myers Squibb Co
Product of Australia. Shipped from AustraliaRxPrescription Required
Kombiglyze XR 5/1000mg from $2.60 USD/tabletKombiglyze XR 5/1000mg
Manufactured by: Astra Zeneca
Product of India. Shipped from IndiaRxPrescription Required
General Information on Kombiglyze XR
Kombiglyze XR contains 2 drugs with generic names metformin and saxagliptin. They are used as medications for oral diabetes and help control blood sugar levels. This medication decreases glucose production in the liver and also ensures that the intestines absorb less glucose. Saxagliptin on the other hand helps regulate the level of insulin that the human body is able to produce after a meal.
This combination of metformin and saxagliptin in Kombiglyze XR is prescribed by doctors for the treatment of type 2 diabetes. If you have symptoms of Type 2 diabetes and if the doctor prescribes the drug, you can buy Kombiglyze XR directly from a pharmacy.
Side effects of Kombiglyze XR
Several different side effects of Kombiglyze XR have been noticed during clinical trials. Some of the symptoms can be caused due to metformin in Kombiglyze XR, saxagliptin, or due to the combination of both. Some of the most common side effects include gas problems, headache accompanied by nausea and vomiting, indigestion, stomach pain followed by an upset stomach and diarrhea, a runny nose, infection in the upper respiratory tract, and a temporary metallic taste in the mouth.
Oral administration of Kombiglyze XR can also lead to severe side effects, some of which are allergic reactions and various symptoms of low blood sugar. Allergic reactions are very common and include rashes, itching skin leading to redness, difficulty breathing, hives, swelling of the face, tightness in the chest, and swelling of the lips and tongue. Some of the symptoms of low blood sugar seen in patients being administered with Kombiglyze XR include fast or rapid heartbeat, increase in hunger, headache and dizziness, anxiety, sweating, chills, tremors, and unexpected changes in vision. Fever and chills can be followed with persistent sore throat and muscle pain. Painful and frequent urination is also a severe side effect. If any of these symptoms persist, then it is advisable to consult a doctor.
It has been noticed through clinical trials that Saxagliptin in Kombiglyze XR can cause respiratory infection, infection in the urinary tract, sinusitis, and gastroenteritis.
You can buy Kombiglyze XR once it has been prescribed, but at the same time, you need to take certain precautions as well. If you have a history of allergy to any form of metformin like Avandamet, Actoplus Met, Glucophage, Fortamet, and Riomet or saxagliptin like Onglyza, then you need to inform your doctor well in advance. If you are already seeking treatment for diabetic ketoacidosis or if you have kidney disease, it is important to consult your doctor before starting Kombiglyze XR treatment. Metformin in Kombiglyze XR can cause lactic acidosis, which can get worse over time and be fatal. If you notice any symptoms of lactic acidosis, stop taking Kombiglyze XR immediately and seek emergency medical help.
Kombiglyze XR Dosage
Kombiglyze XR is an oral medication and can be administered in three doses depending on a patient's requirement. It can be administered as Saxaglipitin 5mg / Metformin 500mg, Saxaglipitin 5mg / Metformin 1000mg, and Saxaglipitin 2.5mg / Metformin 500mg. Kombiglyze XR 5 mg/1000 mg tablets are pink in color, while 2.5 mg/1000 mg tablets are pale yellow in color, and they are both in the shape of capsules. The standard dose is Kombiglyze XR 5mg/500mg, which has to be administered once every day with the evening meal or dinner and needs to be swallowed whole. The doses can be adjusted based on the patient's tolerability and the drug’s effectiveness.
Kombiglyze XR is not known to have any interactions, but it is advisable not to stop the medication or change the dosage without your doctor’s approval.
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What is a "Generic" medication/drug?
Generic drugs are medications that have the comparable medicinal ingredients as the original brand name drug, but which are generally cheaper in price. Nearly 1 in 3 drugs dispensed are "generic". They undergo comparative testing to ensure that they are the same as their "brand" counterparts in:
- Active Ingredient (e.g. "Pravastatin" is the active ingredient in brand name Pravachol)
- Dosage (e.g. 10 mg of the active ingredient)
- Safety (e.g. same or similar side effects, drug interactions)
- Performance (e.g. 10 mg of a "generic" can be substituted for 10 mg of the "brand" and have the same therapeutic result)
- Intended use (e.g. both "generic" and "brand" would be prescribed for the same conditions)
What this means is that "generic" medications can be used as a substitute of their brand equivalents with comparable therapeutic results. There are a few exceptions (examples are outlined at the end of this page) and as always you should consult your physician before switching from a brand name medications to a generic or vice versa.
What differences are there between generic and brand?
While generics and brand equivalent drugs contain comparable active ingredients, they may be different in the following ways:
- Appearance (e.g. the scoring or markings)
The color, shape and size of the medication come from the fillers that are added to the active ingredients to make the drug. These fillers that are added to the drug have no medical use and do not to change the effectiveness of the final product. A generic drug must contain comparable active ingredients and must be comparable in strength and dosage to the original brand name equivalent. Generic drugs can be more cost effective than purchasing the brand name.
Why do generics cost less than the brand name equivalents?
When a new drug is "invented", the company that discovered it has a patent on it that gives them the exclusive production rights for this medication. Once the patent expires in a country, other companies can bring the product to market under their own name. This patent prevents other companies from copying the drug during that time so they can earn back their Research and Development costs through being the exclusive supplier of the product. After the patent expires however, other companies can develop a "generic" version of the product. These versions generally are offered at much lower prices because the companies do not have the same development costs as the original company who developed the medication.
The main thing to realize here though is that the two products are therapeutically comparable. They may look different, and be called something different, but they are required to be have the same active ingredient.
How are Generic drugs tested to ensure quality and efficacy?
The two most generally accepted methods to prove the safety of a generic version of a drug are to either repeat most of the chemistry, animal and human studies originally done, or to show that the drug performs comparably with the original brand name drug. This second option is called a "comparative bioavailability" study. During this type of study, volunteers are given the original drug, and then separately later the generic drug. The rates at which the drug is delivered to the patient (into their blood stream or otherwise absorbed) are measured to ensure they are the same. Because the same active ingredient is used the major concern is just that it delivers the common chemical(s) at the same rate so that they have the same effect. Please note that the methods that the manufacturers use may vary from country to country.